Ignite Creation Date:
2024-05-05 @ 6:37 PM
Last Modification Date:
2024-10-26 @ 9:35 AM
Study NCT ID:
NCT00516581
Status:
COMPLETED
Last Update Posted:
2008-09-05
First Post:
2007-08-14
Brief Title:
Occurrence of Pneumocystis Pneumonia in HIV-Infected Patients and the Interference of the HAART
Sponsor:
UPECLIN HC FM Botucatu Unesp
Organization:
UPECLIN HC FM Botucatu Unesp
Study Overview
Official Title:
Occurrence of Pneumocystis Pneumonia in HIV-Infected Patients and the Interference of the Highly Active Antiretroviral Therapy
Status:
COMPLETED
Status Verified Date:
2008-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
From the beginning of the AIDS epidemic pulmonary pneumocystosis PCP has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality As from 1996 the advent of the highly active antiretroviral therapy HAART has changed the characteristics of such epidemic by reducing its related diseases and as a result AIDS-related mortality With the purpose to estimate PCP occurrence and HAART interference 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002
Detailed Description:
From the beginning of the AIDS epidemic pneumocystis pneumonia PCP has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality As from 1996 the advent of the highly active antiretroviral therapy HAART has changed the characteristics of such epidemic by reducing its related diseases and as a result AIDS-related mortality With the purpose to estimate PCP occurrence and HAART interference 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002 Among them 58 155 PCP cases were found There was a higher occurrence of PCP in the group of patients in which HAART was not used with 40 690 of the episodes As regards the studied period a tendency to a linear reduction in annual PCP incidence was observed The mean of T CD4 lymphocytes in the patients with PCP 117 cellsmm3 was significantly lower when compared to that of the other individuals 325 cellsmm3 Therefore this study suggests a temporal reduction in PCP occurrence related to HAART use with higher T CD4 lymphocyte counts Nevertheless this opportunistic infection still shows significant incidence in AIDS patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| PCP UnespFMB 2003 | None | None | None |