Ignite Creation Date:
2024-05-06 @ 6:09 PM
Last Modification Date:
2024-10-26 @ 2:42 PM
Study NCT ID:
NCT05560035
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-09-29
First Post:
2022-09-26
Brief Title:
The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery
Sponsor:
General Hospital of Ningxia Medical University
Organization:
General Hospital of Ningxia Medical University
Study Overview
Official Title:
Effects of Intravenous Lidocaine on Serum THBS2 MMPS and VEGF-C in Patients Undergoing Radical Hyterectomy Surgery After General Anesthesia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the efficacy of intravenous lidocaine on THBS2 MMPs and VEGF-C in serum in cervical cancer patients undergoing radical hysterectomy under general anesthesia
Detailed Description:
The surgical stress response to tumour removal causes bloodstream release of a variety of pro-inflammatory cytokines and other molecules which may affect perioperative immune response and other conditions conducive to residual tumour cell survival that could later emerge as clinical recurrences or metastasis Lidocaine has analgesic and anti-inflammatory effects and may also have specific anticancer properties
Blood serum expression of these molecules metalloproteinases vascular endothelial growth factor VEGF epidermal growth factor play a important role in the metastatic process and tumor progression lidocaine could affect the course and growth of metastatic tumors by changing the cancer cells the tumor microenvironment or both
We tested the hypothesis that women undergoing cervical cancer resection with these techniques intravenous lidocaine have reduced postoperative serum expression of metastasis biomarkers and may change the outcomes of cancer patients
Blood serum expression of these molecules metalloproteinases vascular endothelial growth factor VEGF epidermal growth factor play a important role in the metastatic process and tumor progression lidocaine could affect the course and growth of metastatic tumors by changing the cancer cells the tumor microenvironment or both
We tested the hypothesis that women undergoing cervical cancer resection with these techniques intravenous lidocaine have reduced postoperative serum expression of metastasis biomarkers and may change the outcomes of cancer patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None