Ignite Creation Date:
2024-05-06 @ 6:08 PM
Last Modification Date:
2024-10-26 @ 2:42 PM
Study NCT ID:
NCT05562687
Status:
COMPLETED
Last Update Posted:
2024-05-07
First Post:
2022-09-28
Brief Title:
Association Between Some Polymorphisms in Apelin Apelin Receptor Genes and Coronary Artery Disease in Syrian Patients
Sponsor:
Damascus University
Organization:
Damascus University
Study Overview
Official Title:
Investigation of Association Between Single Nucleotide Polymorphisms in Genes of the Apelin APJ System -1860TC G212A and CAD Risk and Hypertension in Syrian Patients
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The apelin-APJ signaling pathway has emerged as an important novel mediator of cardiovascular control and blood pressure homeostasis Genetic variation in apelin and its receptors likely contributes to essential hypertension in addition to a range of traditional risk factors Thus a study will be conducted on Syrian patients with hypertension and coronary artery disease to investigate some of the single polymorphisms in the apelin gene and its receptor that may be responsible for the development of these diseases and to link the levels of this peptide and its receptor in the blood with these polymorphisms and the percentage of these diseases as shown by many Modern Global Reference Studies
Detailed Description:
Blood levels of apelin and its receptor will be determined in patients and controls and correlated with hypertension and coronary artery disease And the allelic and genotypic frequencies of the G212A single polymorphism nucleotide of the apelin receptor gene and the -1860TC single polymorphism nucleotide of the apelin gene in the study groups And evaluation the functional role of A allele in hypertension As well as investigating the association between the genotypes of the apelin gene and the levels of apelin in the plasma the genotypes of the apelin receptor gene and the levels of APJ in the plasma in the study groups And link the polymorphism of the apelin gene with the polymorphism of the apelin receptor gene And to determine the correlation between the presence of the studied SNPs and some traditional risk factors for coronary artery disease which are age hypertension the onset age of hypertension smoking BMI cholesterol and triglyceride levels in the blood and family history of CAD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None