Ignite Creation Date:
2024-05-06 @ 6:08 PM
Last Modification Date:
2024-10-26 @ 2:42 PM
Study NCT ID:
NCT05550389
Status:
UNKNOWN
Last Update Posted:
2022-09-22
First Post:
2022-09-19
Brief Title:
Genetics of Pulmonary Hypertension
Sponsor:
Gazi University
Organization:
Gazi University
Study Overview
Official Title:
Genetic Overview of Pulmonary Hypertension
Status:
UNKNOWN
Status Verified Date:
2022-09
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Despite the developments in recent years pulmonary arterial hypertension PAH is still a disease with high mortality and morbidity Although studies on genetic background have increased the pathogenesis of PAH remains complex and unresolved The most comprehensive data are related to bone morphogenetic protein receptor type 2 BMPR2 and in recent years new responsible or candidate genes have been identified especially by new generation DNA sequencing In this study it was aimed to determine the genetic background of patients with PAH and to investigate the genetics of secondary PAH not only HPAH
Detailed Description:
In our study changes in BMPR2 SARS2 KRT8 KRT18 SMAD9 CAV1 KCKN3 CPS1 TBX4 ACVRL1 G6PC3 EIF2AK4 and ENG genes will be screened in patients with PAH In addition to previously reported changes in the relevant genes previously unreported changes that are likely to be significant according to insilico methods are presented
Patients age gender mean follow-up time underlying congenital heart anomalies 6-minute walk test 6 MWT proBNP catheter measurement values mPAB m RAB RpRs PVR vasoreactivity test positivity World health organization functional classification WHO-FS cardiac function measurements by echocardiography treatments they received will be collected retrospectively
Patients age gender mean follow-up time underlying congenital heart anomalies 6-minute walk test 6 MWT proBNP catheter measurement values mPAB m RAB RpRs PVR vasoreactivity test positivity World health organization functional classification WHO-FS cardiac function measurements by echocardiography treatments they received will be collected retrospectively
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None