Ignite Creation Date:
2024-05-06 @ 6:08 PM
Last Modification Date:
2024-10-26 @ 2:42 PM
Study NCT ID:
NCT05550896
Status:
RECRUITING
Last Update Posted:
2023-04-21
First Post:
2022-09-19
Brief Title:
Platelet Adhesion in the Pathobiology of Aortic Stenosis
Sponsor:
University of Virginia
Organization:
University of Virginia
Study Overview
Official Title:
Platelet Adhesion in the Pathobiology of Aortic Stenosis
Status:
RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aortic stenosis AS is a serious and common condition that affects 2-3 of the population 65 years of age in Western countries It is also responsible for extraordinarily high healthcare expenditures estimated to be over 6 billion annually2 in part because the primary treatment for severe AS is aortic valve replacement AVR which is resource-intensive Valve abnormalities are frequently recognized before AS becomes severe or before there is need for guideline-directed procedural intervention thereby providing an opportunity for pharmacologic intervention to slow disease progression Yet all attempts to prevent AS progression in those with degenerative non-congenital forms of disease have failed The only non-procedural intervention that benefits patients with moderate or greater AS is the aggressive treatment of hypertension which reduces net left ventricular LV afterload valvulo-arterial impedance Zva and can slow secondary LV remodeling The overall goal of this proposal is to integrate advanced imaging and vascular biology to study how von Willebrand factor VWF and platelet adhesion promote AS progression through many parallel pathways thereby representing a potential therapeutic target We are hypothesizing that blood markers of abnormal VWF proteolysis and platelet-derived factors and abnormal valve shear patterns which can be detected by advanced analysis of spectral Doppler on echocardiography are predictors for progressive AS
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None