Ignite Creation Date:
2024-05-06 @ 6:07 PM
Last Modification Date:
2024-10-26 @ 2:42 PM
Study NCT ID:
NCT05550662
Status:
RECRUITING
Last Update Posted:
2024-04-16
First Post:
2022-09-19
Brief Title:
HP 129Xe MRI for Evaluation of CLAD in Lung Transplant Recipients
Sponsor:
The Hospital for Sick Children
Organization:
The Hospital for Sick Children
Study Overview
Official Title:
Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Chronic Lung Allograft Dysfunction in Lung Transplant Recipients
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the feasibility of hyperpolarized 129Xe MRI in lung transplant recipients and assess structural and functional pulmonary changes using hyperpolarized 129Xe MRI
Detailed Description:
Lung transplantation is an effective treatment for end-stage lung disease However median survival post-LTx is 6 years This is primarily due to chronic lung allograft dysfunction CLAD
Clinical management of LTx recipients is focused on identifying early risk factors for CLAD by monitoring graft function with spirometry and transbronchial biopsies However both have significant limitations
Hyperpolarized HP noble gas lung MRI 3He and 129Xe allows mapping of both lung anatomy and function 129Xe-MRI could provide a diagnostic tool that is able to detect CLAD more sensitively and earlier than the current gold standard measurements of spirometry and plethysmography and thus allow a means to detect and prevent slow down irreparable and irreversible damage to the lungs in the early stages of disease
Clinical management of LTx recipients is focused on identifying early risk factors for CLAD by monitoring graft function with spirometry and transbronchial biopsies However both have significant limitations
Hyperpolarized HP noble gas lung MRI 3He and 129Xe allows mapping of both lung anatomy and function 129Xe-MRI could provide a diagnostic tool that is able to detect CLAD more sensitively and earlier than the current gold standard measurements of spirometry and plethysmography and thus allow a means to detect and prevent slow down irreparable and irreversible damage to the lungs in the early stages of disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None