Ignite Creation Date:
2024-05-06 @ 6:07 PM
Last Modification Date:
2024-10-26 @ 2:42 PM
Study NCT ID:
NCT05551572
Status:
UNKNOWN
Last Update Posted:
2022-09-22
First Post:
2022-06-10
Brief Title:
Physiopathology of Prosthetic Joint Infections
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Physiopathology of Prosthetic Joint Infections a Pilot Study
Status:
UNKNOWN
Status Verified Date:
2022-09
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROTHEE-PILOTE
Brief Summary:
This study aim to explore cellular responses of bone and immune cells to bacterial infections observed in patients with prosthetic joint infections The investigators will analyze clinical data and tissue samples collected from patients undergoing surgery as part of their usual care for prosthetic joint infections These research will be conducted on three different hospitals in Paris Lariboisière AP-HP Cochin AP-HP and Croix Saint-Simon
Detailed Description:
The number of prosthetic joint infections PJI new cases in France is estimated at 20002500 cases per year PJI mainly caused by staphylococci are serious infections responsible for significant morbidity result of inflammation and bone destruction osteomyelitis Despite optimal medical and surgical management a risk of failure and recurrence exists which varies depending on the situation
In addition to the deterioration in patients quality of life the economic cost for the health care system is very high in particular because of prolonged hospitalizations complex treatments and frequent readmissions Thus the adequate management of PJI is a major public health issue
In this context new therapeutic approaches are urgent medical needs for the management of patients with PJI
Thus the identification of the biological mechanisms immunology microbiology bone physiology underlying these infections is essential Indeed the impact of bacterial infections on bone homeostasis is poorly documented Although several biological mechanisms have been suggested the host-pathogen interaction and the close links between bacterial infection and biological response of bone cells to microorganisms and their environment warrant to be explored
In addition to the deterioration in patients quality of life the economic cost for the health care system is very high in particular because of prolonged hospitalizations complex treatments and frequent readmissions Thus the adequate management of PJI is a major public health issue
In this context new therapeutic approaches are urgent medical needs for the management of patients with PJI
Thus the identification of the biological mechanisms immunology microbiology bone physiology underlying these infections is essential Indeed the impact of bacterial infections on bone homeostasis is poorly documented Although several biological mechanisms have been suggested the host-pathogen interaction and the close links between bacterial infection and biological response of bone cells to microorganisms and their environment warrant to be explored
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None