Ignite Creation Date:
2024-05-06 @ 6:03 PM
Last Modification Date:
2024-10-26 @ 2:40 PM
Study NCT ID:
NCT05524558
Status:
UNKNOWN
Last Update Posted:
2022-09-01
First Post:
2022-08-30
Brief Title:
Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS
Sponsor:
Bicetre Hospital
Organization:
Bicetre Hospital
Study Overview
Official Title:
Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS
Status:
UNKNOWN
Status Verified Date:
2022-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The corner stone of the treatment of ARDS is mechanical ventilation with high levels of positive end-expiratory pressure also called PEEP A high level of PEEP is recommended and frequently used But PEEP can lower cardiac output and contribute to circulatory failure during mechanical ventilation Nevertheless in theory the PEEP-induced pulmonary vascular resistance PVR increase could depend on the level of alveolar recruitment but it has never been proven Thus the aim of this study is to determine the relation between the high-PEEP induced PVR and the alveolar recruitment or overdistension
Detailed Description:
During acute respiratory distress syndrome ARDS the application of positive end-expiratory pressure PEEP prevents expiratory alveolar collapse However it can induce a predominant recruitment effect or on the contrary alveolar overdistension The recruitmentoverdistension ratio can be easily assessed using RI ratio or recruitment-to-inflation ratio However PEEP is likely to lower cardiac output and contribute to the cardiovascular failure that often occurs in patients with ARDS Among its hemodynamic effects PEEP is likely to increase pulmonary vascular resistance and thus right ventricular afterload In theory this effect should only occur if PEEP over-distends the lung volume compressing the extra-alveolar vessels and increasing their resistance However this different effect of PEEP on pulmonary vascular resistance depending on the degree of recruitment or overdistension has never been demonstrated during ARDS in humans
We retrospectively studied data collected from patients with ARDS monitored by pulmonary artery catheter PAC to eventually find a correlation between the high PEEP-induced PVR increase and recruitementoverdistension profile
We retrospectively studied data collected from patients with ARDS monitored by pulmonary artery catheter PAC to eventually find a correlation between the high PEEP-induced PVR increase and recruitementoverdistension profile
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None