Ignite Creation Date:
2024-05-06 @ 6:00 PM
Last Modification Date:
2024-10-26 @ 2:39 PM
Study NCT ID:
NCT05502705
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-08-16
First Post:
2022-07-25
Brief Title:
The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients
Sponsor:
General Hospital of Ningxia Medical University
Organization:
General Hospital of Ningxia Medical University
Study Overview
Official Title:
Effects of Intravenous Lidocaine on Serum BDNF NGF miRNA-206 and miRNA-98 in Elderly Patients Undergoing Abdominal Surgery Under General Anesthesia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF NGF miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia
Detailed Description:
Postoperative cognitive dysfunction POCD is a major complication following surgeries and anesthesia especially in elderly individuals Lidocaine an inexpensive widely available and relatively safe compound is a local anesthetic that readily crosses the blood-brain barrier Intravenous lidocaine can reduce the incidence of POCD However the mechanism is still unclear
Brain-derived neurotrophic factor BDNF and nerve growth factor NGF which are regulated by miRNA-206 and miRNA-98 respectively play a key role in learning memory and cognition Previous studies have shown that the levels of BDNF and NGF can be improved by lidocaine
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD and the levels of BDNF NGF miRNA-206 and miRNA-98 in elderly patients undergoing abdominal surgery under general anesthesia
Brain-derived neurotrophic factor BDNF and nerve growth factor NGF which are regulated by miRNA-206 and miRNA-98 respectively play a key role in learning memory and cognition Previous studies have shown that the levels of BDNF and NGF can be improved by lidocaine
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD and the levels of BDNF NGF miRNA-206 and miRNA-98 in elderly patients undergoing abdominal surgery under general anesthesia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None