Ignite Creation Date:
2024-05-05 @ 6:34 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00503958
Status:
UNKNOWN
Last Update Posted:
2013-05-15
First Post:
2007-07-17
Brief Title:
Liverpool Lung Project Risk Factors and Genetic Markers in Healthy Participants and Patients With Lung Cancer
Sponsor:
University of Liverpool Cancer Research Centre
Organization:
National Cancer Institute NCI
Study Overview
Official Title:
Liverpool Lung Project
Status:
UNKNOWN
Status Verified Date:
2007-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Environmental exposure and genetic predisposition may affect the risk of developing cancer later in life Learning about genetic markers and the long-term effects of environmental exposure may help the study of lung cancer in the future
PURPOSE This research study is looking at risk factors and genetic markers in healthy participants and in patients with lung cancer
PURPOSE This research study is looking at risk factors and genetic markers in healthy participants and in patients with lung cancer
Detailed Description:
OBJECTIVES
To prepare a molecular genetic and epidemiological risk assessment model based on the analysis of environmental exposures and genetic predisposition which will provide an algorithm to measure an individuals risk for developing lung cancer
To develop an archive of specimens relating to at-risk individuals and those with lung cancer
To redefine lung cancer based on molecular pathology using the fields of expression and methylation profiling and genetic instability
To identify and assess novel markers of pre-carcinogenesis in our high-risk populations
To facilitate the development of new intervention strategies ie chemoprevention
OUTLINE This is a multicenter study
Participants andor patients undergo tumor tissue sputum and blood sample collection periodically Samples are analyzed via fields of expression and methylation profiling and genetic instability Samples are also archived
Complete lifetime lifestyle residential environmental tobacco smoke and occupational history are assessed in the first year and then in year five and year ten Participants who return for follow-up complete a shorter questionnaire aimed at recording change over the interval since their last attendance
PROJECTED ACCRUAL 800 patients and 7500 healthy participants will be accrued for this study
To prepare a molecular genetic and epidemiological risk assessment model based on the analysis of environmental exposures and genetic predisposition which will provide an algorithm to measure an individuals risk for developing lung cancer
To develop an archive of specimens relating to at-risk individuals and those with lung cancer
To redefine lung cancer based on molecular pathology using the fields of expression and methylation profiling and genetic instability
To identify and assess novel markers of pre-carcinogenesis in our high-risk populations
To facilitate the development of new intervention strategies ie chemoprevention
OUTLINE This is a multicenter study
Participants andor patients undergo tumor tissue sputum and blood sample collection periodically Samples are analyzed via fields of expression and methylation profiling and genetic instability Samples are also archived
Complete lifetime lifestyle residential environmental tobacco smoke and occupational history are assessed in the first year and then in year five and year ten Participants who return for follow-up complete a shorter questionnaire aimed at recording change over the interval since their last attendance
PROJECTED ACCRUAL 800 patients and 7500 healthy participants will be accrued for this study
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| EU-20735 | Registry Identifier | PDQ Physician Data Query | None |
| CDR0000554297 | REGISTRY | None | None |