Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001224
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Analysis of Eye Tissue
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Immunologic Analysis of Intra-Ocular Tissue
Status:
COMPLETED
Status Verified Date:
2002-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this investigation is to better understand the inflammatory process that occurs in uveitis eye inflammation through study of eye tissues
Patients with uveitis sometimes develop cataracts clouding of the lens of the eye or clouding of the vitreous-the gel-like material behind the lens-that can impair eyesight Those who require cataract surgery or vitrectomy are eligible for this study Samples of eye tissue and fluid normally removed during standard surgical procedures for these conditions will be given to researchers instead of discarded as is usually done
Before surgery patients will undergo routine preoperative tests including chest X-ray electrocardiogram blood tests and urinalysis They will also have an eye examination and photographs taken of the retina Other tests that may be performed include fluorescein angiography to evaluate the blood vessels of the retina ultrasound to examine the back of the eye and a gallium scan to evaluate inflammation
Immune cells in the blood and eye tissue will be compared and categorized by disease The eye fluid will be examined for substances involved in the inflammatory process These studies may provide information that will lead to improved methods of diagnosis and treatment
Patients with uveitis sometimes develop cataracts clouding of the lens of the eye or clouding of the vitreous-the gel-like material behind the lens-that can impair eyesight Those who require cataract surgery or vitrectomy are eligible for this study Samples of eye tissue and fluid normally removed during standard surgical procedures for these conditions will be given to researchers instead of discarded as is usually done
Before surgery patients will undergo routine preoperative tests including chest X-ray electrocardiogram blood tests and urinalysis They will also have an eye examination and photographs taken of the retina Other tests that may be performed include fluorescein angiography to evaluate the blood vessels of the retina ultrasound to examine the back of the eye and a gallium scan to evaluate inflammation
Immune cells in the blood and eye tissue will be compared and categorized by disease The eye fluid will be examined for substances involved in the inflammatory process These studies may provide information that will lead to improved methods of diagnosis and treatment
Detailed Description:
The purpose of this project is to evaluate intra-ocular tissue such as iris or vitreous from uveitis patients in order to analyze the type and character of the inflammatory response Patients with a history of uveitis who require cataract surgery or vitreous surgery because of the clinical complications of inflammation will be entered in this study The lymphocyte subsets in the peripheral blood and ocular tissue will be compared and categorized by disease The presence of soluble lymphokines in the intra-ocular fluid will be analyzed Long term cell cultures of vitreal cells will be attempted to define the T-cell receptors In addition a portion of iris tissue or vitreous cells will be frozen to establish a tissue library of uveitis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 87-EI-0104 | None | None | None |