Ignite Creation Date:
2024-05-06 @ 5:57 PM
Last Modification Date:
2024-10-26 @ 2:39 PM
Study NCT ID:
NCT05496673
Status:
RECRUITING
Last Update Posted:
2023-09-05
First Post:
2022-08-09
Brief Title:
Meningitis Burden Causes Screening and Prevention in Rural Northern Uganda
Sponsor:
University of Rochester
Organization:
University of Rochester
Study Overview
Official Title:
Meningitis Burden Causes Screening and Prevention in Rural Northern Uganda
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate the burden causes diagnostics treatments and preventive measures related to meningitis in northern Uganda We hypothesize that understanding the burden of meningitis risk factors diagnostics treatments and the preventive measures will provide information regarding the gaps in care that can be addressed in order to improve the continuum of meningitis care we hypothesize that our data will support the advocacy for the implementation of routine vaccination for the prevention of bacterial meningitis and improving guidelines for Cryptococcal antigen CrAg screening for prevention of cryptococcal meningitis which will save lives in Uganda
Aim 1 To prospectively collect data on 1100 patients with meningitis and meningitis symptoms who were admitted to Lira Regional Referral Hospital LRRH to assess burden etiologies pathogenesis and outcomes of meningitis using modern diagnostic testing not previously available in Uganda
Aim 2 To perform CrAg screening of 10000 HIV-positive patients to determine the prevalence of cryptococcal antigenemia infection and conduct a case control study to compare risk factors and outcomes among CrAg-positive patients and matched CrAg-negative controls based on age sex TB status ART experience CD4 count and viral load
Aim 1 To prospectively collect data on 1100 patients with meningitis and meningitis symptoms who were admitted to Lira Regional Referral Hospital LRRH to assess burden etiologies pathogenesis and outcomes of meningitis using modern diagnostic testing not previously available in Uganda
Aim 2 To perform CrAg screening of 10000 HIV-positive patients to determine the prevalence of cryptococcal antigenemia infection and conduct a case control study to compare risk factors and outcomes among CrAg-positive patients and matched CrAg-negative controls based on age sex TB status ART experience CD4 count and viral load
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R21TW012439 | NIH | None | httpsreporternihgovquickSearchR21TW012439 |