Ignite Creation Date:
2024-05-06 @ 5:57 PM
Last Modification Date:
2024-10-26 @ 2:38 PM
Study NCT ID:
NCT05491122
Status:
UNKNOWN
Last Update Posted:
2022-08-08
First Post:
2022-08-01
Brief Title:
The Influence of Fluid Intake on Daily Biological Rhythm and Mental Performance in Healthy Young Adults
Sponsor:
Liverpool John Moores University
Organization:
Liverpool John Moores University
Study Overview
Official Title:
Investigating the Influence of Fluid Intake on Saliva Cortisol Diurnal Variation and Acute Response to Psychological Stress in Young Adults
Status:
UNKNOWN
Status Verified Date:
2022-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic low water intake may raise the risk of morbidity and mortality by influencing key water regulating hormones eg AVP which are known to modulate glucoregulation and renal function For example AVP stimulates the HPA axis to release the glucocorticoid stress hormone cortisol with potentially far-reaching effects on metabolism immunity and inflammation One study observed elevated blood cortisol in a group of low water drinkers albeit cortisol was measured at one time of day only However in the field of psychobiology researchers have traditionally related more dynamic assessments of cortisol with health outcomes by evoking cortisol responses to acute standardised laboratory stressors such as The Trier social stress test More recently researchers have appreciated the importance of circadian variability in cortisol levels by examining influences on and consequences of individual differences in the diurnal variation of cortisol The major measurable parameters of the diurnal variation are the cortisol awakening response CAR which is the rise in cortisol during the first 30-45 minutes following awakening and the diurnal cortisol slope which is the rate of decline in cortisol levels across the day from morning to evening These parameters are considered to reflect different aspects of HPA axis function with the CAR best reflecting the adrenal capacity to respond to stress and awakening and diurnal slope more indicative of daily cortisol exposure Although distinct both blunted CAR and a flattened diurnal cortisol slope appear to be consistent markers of HPA axis dysfunction and related to a variety of poor health outcomes Therefore it has been recommended that contemporary research should simultaneously estimate an individuals awakening cortisol responsiveness and diurnal slope thereby capturing distinct and important components of HPA axis function The shared pathways that regulate body water diurnal variation in cortisol and our response to stress underpin the broad aim of this research programme to investigate the influence of low and high fluid intake on diurnal cortisol variation and the cortisol response to acute stress
The aims of this study are to investigate
1 The influence of a change in water intake behaviour on diurnal saliva cortisol variation as assessed by the CAR primary outcome
2 The influence of a change in water intake behaviour on biomarkers of hydration and thirst as assessed by urine osmolality urine colour and thirst sensation
3 The influence of habitual low and high total fluid intake on saliva cortisol response to an acute psychological stress secondary outcome
4 Investigate the influence of a change in water intake behaviour on plasma biomarkers of hydration as assessed by plasma osmolality and plasma copeptin exploratory outcome
The aims of this study are to investigate
1 The influence of a change in water intake behaviour on diurnal saliva cortisol variation as assessed by the CAR primary outcome
2 The influence of a change in water intake behaviour on biomarkers of hydration and thirst as assessed by urine osmolality urine colour and thirst sensation
3 The influence of habitual low and high total fluid intake on saliva cortisol response to an acute psychological stress secondary outcome
4 Investigate the influence of a change in water intake behaviour on plasma biomarkers of hydration as assessed by plasma osmolality and plasma copeptin exploratory outcome
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None