Ignite Creation Date:
2024-05-06 @ 5:56 PM
Last Modification Date:
2024-10-26 @ 2:38 PM
Study NCT ID:
NCT05485688
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-11-07
First Post:
2022-08-01
Brief Title:
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
Sponsor:
Taipei Veterans General Hospital Taiwan
Organization:
Taipei Veterans General Hospital Taiwan
Study Overview
Official Title:
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This prospective observational study will enroll 60 moderate-to-severe OSA patients AHI15hour 30 obese BMI27 30 non-obese BMI27 and 40 age- gender- BMI-matched controls without OSA Venous blood 10 ml will be collected to isolate neutrophils which are later tested for their ability to produce neutrophil extracellular traps NETs under the effect of PMA phorbol 12-myristate 13-acetate The test will be repeated if OSA patients receive CPAP therapy continous positive airway pressure therapy
Detailed Description:
Obstructive sleep apnea OSA is a common disease affecting around one billion people worldwide This disorder is characterized by repetitive upper airway collapse during sleep thereby leading to intermittent hypoxia IH The severity of OSA is gauged by AHIapnea-hypopnea index which can be determined by a sleep test polysomnography Literature revealed OSA confers a higher risk for incident pneumonia and sepsis-related adverse outcomes suggestive of defective immunity in those patients CPAP therapy continous positive airway pressure therapy is the mainstay treatment for OSA This research is aimed to investigate the impact of IH on the ability of neutrophils to produce neutrophil extracellular traps NETs We will enroll 60 moderate-to-severe OSA patients AHI15hour 30 obese BMI27 30 non-obese BMI27 and 40 age- gender- BMI-matched controls without OSA Venous blood 10 ml will be collected to isolate neutrophils which are later tested for their ability to produce NETs under the effect of PMA phorbol 12-myristate 13-acetate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None