Ignite Creation Date:
2024-05-05 @ 6:34 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00502645
Status:
COMPLETED
Last Update Posted:
2007-07-17
First Post:
2007-07-15
Brief Title:
Clinical Risk Assesment of CS-1 Decision Support System
Sponsor:
Medical University of Graz
Organization:
Medical University of Graz
Study Overview
Official Title:
SINGLE-CENTEROPENNON-CONTROLLED FEASIBILITY STUDY ON THE PERFORMANCE OF THE CS-1 DECISION SUPPORT SYSTEM WITH INCORPORATED SOFTWARE-ALGORITHM eMPC USED FOR BLOOD GLUCOSE CONTROL OVER 72 HOURS IN CRITICALLY ILL PATIENTS AT THE INTENSIVE CARE UNIT
Status:
COMPLETED
Status Verified Date:
2007-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a single-center open non-controlled clinical investigation in 10 patients at the Medical University Graz including a treatment visit V1and a follow up visitV2 In the treatment visit V1 after admittance to the ICU arterial blood glucose values will be monitored and either the software-algorithm eMPC will be used to adjust the infusion rate of intravenously administered human soluble insulin to normalise arterial blood glucose The purpose of the present study is to investigate the performance of the already developed and tested algorithm in combination with a newly developed bed-side touch screen user interface CS-1 decision support system in patients at the medical ICU for a period of 72 hours Follow up informationV2 will be acquired at hospital discharge or at the latest one week after visit 1
Detailed Description:
Before the beginning of any trial related activities the relatives of each patient will be asked if the patient has ever mentioned in the past that heshe does not want do participate in any kind of clinical study If this was said by the patient in the past or if there are any signs which make it likely that the patient would not participate heshe will be excluded from the trial After testing of the inclusion and exclusion criteria screening information will be obtained a the beginning of the trial A screening number will be assigned to the patient in ascending order The following data will be recorded in the case record form CRF Check for inclusionexclusion criteriademographic data medical including diabetes history and relevant medication body weight and heightand laboratory analyses from routine laboratory assessment Patients fulfilling all the inclusion criteria and none of the exclusion criteria will be included into the trial and a subject number will be assigned in ascending order Routine intensive care will be provided from department of internal medicine Trial related activities will not interfere with regular patient care Blood samples will be retrieved from an arterial line available for routine diagnostic and monitoring procedures in all patients At time 0 a blood glucose measurement will be taken manually entered into the CS-1 decision support system and both a insulin infusion rate and the time to next glucose reading will be suggested by the computer-based system Based on the suggestion of the system an insulin infusion pump as routinely used in the ICU will be manually set to this suggested insulin infusion rate by specially trained ICU staff but only if the staff feels safe with this suggestion Intravenous infusion of human soluble insulin will then be started For safety reasons In case that the suggested measurement interval of the decision support system exceeds a 90 minute interval interim glucose measurements will be taken All measurements will be documented in the CRF Only in case that the blood glucose values are below 40 mgdl the additional interim-glucose value will also be put into the CS-1 system However the nursing staff can at any time decide to take an additionlal blood glucose measurement andor neglect the decision as suggested by the system
The target range for blood glucose levels will be 80-110 mgdl 44 - 61 mmoll The current blood glucose level and insulin infusion rate will continuously be documented by the CS-1 decision support system and supervised by the investigator Glucose values will be provided to the system by manual entry In case of hypoglycaemia intravenous insulin infusion will be stopped and glucose will be administered via intravenous bolus
The treatment visit including all trial related activities as described above will last for 72 hours Adverse events and relevant medication will be continuously monitored and documented The Acute Physiology and Chronic Health Evaluation Score Apache II will be documented for each patient at the beginning of the trial There is no physical connection between the algorithm suggesting the insulin infusion rate and the insulin infusion pump such as that the algorithm would be capable to independently steer the insulin infusion There is also no physical connection between the glucose measurement device and the algorithm such as that the algorihthm would be able to independently get a glucose measurement For safety reasons both the glucose measurement and the insulin infusion rate are parameters that need to be manually entered by a specially trained nurse For glucose measurement a certified device for ICU application is being used Accuchek Inform Roche Diagnostics for intravenous insulin infusion a certified insulin infusion pump Perfusor Space BBraun Melsungen as it is used under routine conditions in the ICU is being used Follow up information will be acquired at hospital discharge or at the latest one week after visit 1
The target range for blood glucose levels will be 80-110 mgdl 44 - 61 mmoll The current blood glucose level and insulin infusion rate will continuously be documented by the CS-1 decision support system and supervised by the investigator Glucose values will be provided to the system by manual entry In case of hypoglycaemia intravenous insulin infusion will be stopped and glucose will be administered via intravenous bolus
The treatment visit including all trial related activities as described above will last for 72 hours Adverse events and relevant medication will be continuously monitored and documented The Acute Physiology and Chronic Health Evaluation Score Apache II will be documented for each patient at the beginning of the trial There is no physical connection between the algorithm suggesting the insulin infusion rate and the insulin infusion pump such as that the algorithm would be capable to independently steer the insulin infusion There is also no physical connection between the glucose measurement device and the algorithm such as that the algorihthm would be able to independently get a glucose measurement For safety reasons both the glucose measurement and the insulin infusion rate are parameters that need to be manually entered by a specially trained nurse For glucose measurement a certified device for ICU application is being used Accuchek Inform Roche Diagnostics for intravenous insulin infusion a certified insulin infusion pump Perfusor Space BBraun Melsungen as it is used under routine conditions in the ICU is being used Follow up information will be acquired at hospital discharge or at the latest one week after visit 1
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None