Ignite Creation Date:
2024-05-06 @ 5:56 PM
Last Modification Date:
2024-10-26 @ 2:38 PM
Study NCT ID:
NCT05488587
Status:
UNKNOWN
Last Update Posted:
2022-08-09
First Post:
2022-07-19
Brief Title:
Serum Levels of Some Trace Elements in Hepatocellular Carcinoma Patients
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Serum Levels of Some Trace Elements in Hepatocellular Carcinoma Patients
Status:
UNKNOWN
Status Verified Date:
2022-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hepatocellular carcinoma HCC is the sixth most frequent malignancy worldwide with an estimated 906000 new cases and 830000 deaths in 2020 It is also the third leading cause for cancer deaths with 15 5-year survival rate
Diagnosis of HCC in cirrhotic patients is mainly based on non-invasive imaging techniques Multiphasic computed tomography CT and dynamic contrast-enhanced magnetic resonance imaging MRI are the most sensitive imaging techniques for diagnosis of HCC While the most common serologic marker for early screening of HCC is alpha-fetoprotein AFP
Liver is the main site of trace elements metabolism and their levels are affected by different causes of liver disease
Diagnosis of HCC in cirrhotic patients is mainly based on non-invasive imaging techniques Multiphasic computed tomography CT and dynamic contrast-enhanced magnetic resonance imaging MRI are the most sensitive imaging techniques for diagnosis of HCC While the most common serologic marker for early screening of HCC is alpha-fetoprotein AFP
Liver is the main site of trace elements metabolism and their levels are affected by different causes of liver disease
Detailed Description:
Hepatocellular carcinoma HCC is the sixth most frequent malignancy worldwide with an estimated 906000 new cases and 830000 deaths in 2020 It is also the third leading cause for cancer deaths with 15 5-year survival rate
Diagnosis of HCC in cirrhotic patients is mainly based on non-invasive imaging techniques Multiphasic computed tomography CT and dynamic contrast-enhanced magnetic resonance imaging MRI are the most sensitive imaging techniques for diagnosis of HCC While the most common serologic marker for early screening of HCC is alpha-fetoprotein AFP
Liver is the main site of trace elements metabolism and their levels are affected by different causes of liver disease Zinc Zn is an essential trace element which is required for the function of numerous enzymatic molecules active in human cell metabolic pathways Zn plays an important role in cell growth differentiation apoptosis and metabolism with more than 300 proteins that regulate cellular functions containing Zn-binding domains Zn protects against carcinogenesis as it helps activation of deoxyribonucleic acid DNA repair enzymes Also it is a component of superoxide dismutase an enzyme that removes free radicals
Zn deficiency was reported to be associated with increased liver fibrosisand hepatitis C virus HCV related HCC Zn deficiency is also associated with complications related to liver cirrhosis such as sarcopenia and hepatic encephalopathy
Magnesium Mg as a co-factor for up to 600 enzymes has a fundamental role in many physiological and biochemical functions including cell proliferation DNA repair and energy metabolism
The available data indicate an opposite role of Mg in the oncology field Many authors showed that a high content of Mg in the diet is associated with a lower incidence of gastric colon and breast cancers However various data showed that the availability of Mg by cancerous tissues could be involved in the development andor growth of tumors
A little is known about the significance of Mg in liver disease A negative association of primary liver cancer with dietary intake of Mg has been demonstrated
Diagnosis of HCC in cirrhotic patients is mainly based on non-invasive imaging techniques Multiphasic computed tomography CT and dynamic contrast-enhanced magnetic resonance imaging MRI are the most sensitive imaging techniques for diagnosis of HCC While the most common serologic marker for early screening of HCC is alpha-fetoprotein AFP
Liver is the main site of trace elements metabolism and their levels are affected by different causes of liver disease Zinc Zn is an essential trace element which is required for the function of numerous enzymatic molecules active in human cell metabolic pathways Zn plays an important role in cell growth differentiation apoptosis and metabolism with more than 300 proteins that regulate cellular functions containing Zn-binding domains Zn protects against carcinogenesis as it helps activation of deoxyribonucleic acid DNA repair enzymes Also it is a component of superoxide dismutase an enzyme that removes free radicals
Zn deficiency was reported to be associated with increased liver fibrosisand hepatitis C virus HCV related HCC Zn deficiency is also associated with complications related to liver cirrhosis such as sarcopenia and hepatic encephalopathy
Magnesium Mg as a co-factor for up to 600 enzymes has a fundamental role in many physiological and biochemical functions including cell proliferation DNA repair and energy metabolism
The available data indicate an opposite role of Mg in the oncology field Many authors showed that a high content of Mg in the diet is associated with a lower incidence of gastric colon and breast cancers However various data showed that the availability of Mg by cancerous tissues could be involved in the development andor growth of tumors
A little is known about the significance of Mg in liver disease A negative association of primary liver cancer with dietary intake of Mg has been demonstrated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None