Ignite Creation Date:
2024-05-06 @ 5:56 PM
Last Modification Date:
2024-10-26 @ 2:38 PM
Study NCT ID:
NCT05485571
Status:
UNKNOWN
Last Update Posted:
2022-08-03
First Post:
2022-07-24
Brief Title:
Efficacy of Combined Microneedling With Methotrexate in Treatment of Alopecia Areata
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Efficacy of Combined Microneedling With Methotrexate in Treatment of Alopecia Areata
Status:
UNKNOWN
Status Verified Date:
2022-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Alopecia areata AA is a common cause of non-cicatricial hair loss It is the second-most frequent non-scarring alopecia after androgenic alopecia
The prevalence of the disease is 02 in the general population with higher prevelance in younger 21-40 years of age patients but no significant difference in incidence between males and females
Several treatment options such as corticosteroids anthralin topical minoxidil immunotherapy and systemic therapy are commonly used with varying response Unfortunately the traditional treatment options are frequently disappointing Available treatments may induce regrowth but do not modify the disease course
Methotrexate MTX is a folic acid analog that binds to the dihydrofolate reductase enzyme blocking the formation of tetrahydrofolate and so inhibits purine and pyrimidine metabolism and consequently nucleic acid synthesis It acts as an immunosuppressant used in the treatment of several skin diseases Systemic MTX has been used in the treatment of AA with satisfactory results Microneedling is a minimally invasive procedure that utilizes multiple fine needles to create micropunctures in the skinThe act of creating these two to four cell-wide puncture holes triggers neovascularization release of growth factors and stimulates the expression of Wnt proteins it has specifically been demonstrated to increase hair regrowth in alopecia via the release of platelet-derived growth factor epidermal growth factors and activation of the hair bulge all of which are triggered by the wound healing response Increased expression of Wnt proteins namely Wnt3a and Wnt10b is also evident following microneedling These particular proteins have been demonstrated to stimulate dermal papillae stem cells and hair growth
The prevalence of the disease is 02 in the general population with higher prevelance in younger 21-40 years of age patients but no significant difference in incidence between males and females
Several treatment options such as corticosteroids anthralin topical minoxidil immunotherapy and systemic therapy are commonly used with varying response Unfortunately the traditional treatment options are frequently disappointing Available treatments may induce regrowth but do not modify the disease course
Methotrexate MTX is a folic acid analog that binds to the dihydrofolate reductase enzyme blocking the formation of tetrahydrofolate and so inhibits purine and pyrimidine metabolism and consequently nucleic acid synthesis It acts as an immunosuppressant used in the treatment of several skin diseases Systemic MTX has been used in the treatment of AA with satisfactory results Microneedling is a minimally invasive procedure that utilizes multiple fine needles to create micropunctures in the skinThe act of creating these two to four cell-wide puncture holes triggers neovascularization release of growth factors and stimulates the expression of Wnt proteins it has specifically been demonstrated to increase hair regrowth in alopecia via the release of platelet-derived growth factor epidermal growth factors and activation of the hair bulge all of which are triggered by the wound healing response Increased expression of Wnt proteins namely Wnt3a and Wnt10b is also evident following microneedling These particular proteins have been demonstrated to stimulate dermal papillae stem cells and hair growth
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None