Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005508
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Determinants of Coronary Disease in High Risk Families
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To define factors contributing to coronary heart disease CHD in high risk families
Detailed Description:
DESIGN NARRATIVE
The study followed healthy siblings of patients diagnosed with CHD before age 60 All siblings underwent comprehensive risk factor screening and exercise thallium tomography to identify occult CHD Follow-up was performed from 6-15 years after entry mean 87 years to determine the incidence of 1 acute coronary events sudden death myocardial infarction and unstable angina and 2 progression of occult CHD repeat exercise thallium tomography Blood was obtained for genomic DNA which was tested for polymorphisms of candidate genes which may be associated with premature thrombotic CHD events platelet proteins GPIIBIIIaPlA1A2 and Bakab and GPIbB endothelial nitric oxide synthase angiotensin converting enzyme angiotensinogen D-fibrinogen plasminogen activator-1 and methylenetetrahydrofolate reductase Plasma levels of proteins implicated in the pathogenesis of atherosclerosis and thrombotic CHD events were measured fibrinogen plasminogen activator inhibitor-1 tissue plasminogen activator homocysteine lipoprotein a and apoa isoform size DNA was also obtained from living probands and affected siblings to use for genetic linkage studies using affected and unaffectedsibling pairs Statistical analyses examined 1 whether selected genetic polymorphisms were linked to the occurrence of acute CHD events and 2 to what extent traditional sociodemographic and biological coronary risk factors or new genetic polymorphisms explained the progression of occult CHD or the transition from occult to symptomatic CHD events in families with premature CHD
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The study followed healthy siblings of patients diagnosed with CHD before age 60 All siblings underwent comprehensive risk factor screening and exercise thallium tomography to identify occult CHD Follow-up was performed from 6-15 years after entry mean 87 years to determine the incidence of 1 acute coronary events sudden death myocardial infarction and unstable angina and 2 progression of occult CHD repeat exercise thallium tomography Blood was obtained for genomic DNA which was tested for polymorphisms of candidate genes which may be associated with premature thrombotic CHD events platelet proteins GPIIBIIIaPlA1A2 and Bakab and GPIbB endothelial nitric oxide synthase angiotensin converting enzyme angiotensinogen D-fibrinogen plasminogen activator-1 and methylenetetrahydrofolate reductase Plasma levels of proteins implicated in the pathogenesis of atherosclerosis and thrombotic CHD events were measured fibrinogen plasminogen activator inhibitor-1 tissue plasminogen activator homocysteine lipoprotein a and apoa isoform size DNA was also obtained from living probands and affected siblings to use for genetic linkage studies using affected and unaffectedsibling pairs Statistical analyses examined 1 whether selected genetic polymorphisms were linked to the occurrence of acute CHD events and 2 to what extent traditional sociodemographic and biological coronary risk factors or new genetic polymorphisms explained the progression of occult CHD or the transition from occult to symptomatic CHD events in families with premature CHD
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL059684 | NIH | None | httpsreporternihgovquickSearchR01HL059684 |