Ignite Creation Date:
2024-05-06 @ 5:53 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05464264
Status:
RECRUITING
Last Update Posted:
2023-11-29
First Post:
2022-06-24
Brief Title:
Auditory MMN EEG in TRD in Response to Ketamine
Sponsor:
Unity Health Toronto
Organization:
Unity Health Toronto
Study Overview
Official Title:
Deciphering Metacognition and Treatment Response in Depression With a Novel Digital Paradigm
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To develop and test a neurocomputational model of ketamine treatment response predictions in TRD
Detailed Description:
The investigators propose applying a previously validated computational model of the MMN and the ensuing effects of NMDAR antagonism to predict treatment response following ketamine infusions in TRD patients and distinguish ketamines antisuicidal effects from those related to mood improvements The study has two subgoals first the computational mechanisms underlying MMN reductions that predict ketamine treatment response in TRD patients will be examined Second the computational mechanisms will be linked to their underlying neural causes using neural circuit models Beyond understanding ketamines short- and long-term mechanisms of action in TRD the parameters obtained from fitting these models to noninvasive EEG recordings may facilitate single-patient treatment predictions If successful this approach may provide clinically useful prognostic statements in individual patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None