Ignite Creation Date:
2024-05-06 @ 5:53 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05460572
Status:
UNKNOWN
Last Update Posted:
2022-07-15
First Post:
2022-07-05
Brief Title:
Cardiac Metabolic Profiling in the Fed State
Sponsor:
University Medical Center Groningen
Organization:
University Medical Center Groningen
Study Overview
Official Title:
Cardiac Metabolic Profiling in the Fed State
Status:
UNKNOWN
Status Verified Date:
2022-07
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAMP
Brief Summary:
This is a non-randomized interventional prospective study aiming to provide insight into cardiac substrate utilization in the fed state Patients will participate during an elective PVI procedure which would have taken place regardless of the current study During this study study subjects will receive peripheral parenteral nutrition PPN through an intravenous iv line During the procedure blood samples will be drawn from the catheters which will be in situ for the purpose of the elective PVI procedure Cardiac arteriovenous A-V gradients of metabolites will be measured reflecting cardiac uptake and release of metabolites in the fed state
Detailed Description:
The heart requires tremendous amounts of energy to sustain its continuous mechanical work The heart can utilize various metabolic substrates to generate energy including carbohydrates lipids amino acids and ketone bodies However most research on cardiac fuel use has been done in rodents and surprisingly little is known about cardiac fuel use in patients with heart disease Prior experimental studies showed that carbohydrates are important fuels for cardiac energy production In contrast a recent study in patients with heart disease showed that the heart only utilizes little amounts of carbohydrates This study was however performed in fasting subjects which could have an important effect on substrate preference The primary aim of this non-randomized interventional prospective study is to provide insight into cardiac substrate utilization in the fed state Patients will participate during an elective PVI procedure which would have taken place regardless of the current study During this study they will receive peripheral parenteral nutrition PPN through an intravenous iv line Blood samples will be drawn with the catheters which will already be in situ for the purpose of the elective PVI procedure Cardiac arteriovenous A-V gradients of metabolites will be measured reflecting cardiac uptake and release of metabolites in the fed state
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None