Ignite Creation Date:
2024-05-06 @ 5:52 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05464797
Status:
COMPLETED
Last Update Posted:
2022-07-19
First Post:
2022-07-11
Brief Title:
Diagnostic Biomarkers to Correlate Molecular Changes and Inflammatory Cascade in the Dental Pulp
Sponsor:
Mansoura University
Organization:
Mansoura University
Study Overview
Official Title:
Diagnostic Biomarkers to Correlate Molecular Changes and Early Inflammatory Cascade in Deep Carious Lesions With Dental Pulp Exposure
Status:
COMPLETED
Status Verified Date:
2020-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities Direct pulp capping Partial Pulpotomy and Complete Pulpotomy
Detailed Description:
The diagnosis of irreversible pulpitis was based only on the clinical signs and symptoms which does not always match that of the histological changes of the pulp tissues So it is more appropriate to diagnose the pulp according to the molecular changes taking place throughout the pulp tissues Different studies have been conducted to study the molecular changes that take place in the inflamed pulp Including a study that was conducted by Rechenberg et al in 2014 which states different locations to obtain samples for these molecules The best of which was the dental pulp blood sample Many studies stated the way to obtain a blood sample from the pulp and how to prepare and test it to evaluate the levels and concentrations of different inflammatory molecules Many studies were also conducted to study the different changes and accurateness of measurement of different molecules
The pulp inflammation occurs in a low compliance environment of dentinal walls So During acute inflammatory reaction Vasodilatation occurs along with increased capillary permeability Which leads to increase in the pulp interstitial fluid pressure which creates more pressure on blood vessels and this prevents beneficial blood flow which decreases the ability of the pulp to defend itself from bacterial attacks causing tissue necrosis This necrotic tissue is colonized by bacterial tissues
In the literature one of the novel treatment modalities for irrevesible inflammation of the pulp is partial removal of the inflammed pulp tissue according to clinical sign bleeding control The pulp tissue is removed partially until reaching complete coronal pulp removal or complete pulpectomy until hemostasis is obtained after 10 minutes of moist cotton pellet applicationSo The normal pulp is preserved
In 2019 Ricucci et al conducted a systematic review for treatment of deep carious lesions with pulp exposure With treatment modalities ranging from direct pulp capping partial pulpotomy complete pulpotomy and pulpectomy Based only on clinical signs of normal appearance of the pulp tissue under magnification with dental operating microscope and bleeding control within 10 minutes with a moist cotton pellet
The pulp inflammation occurs in a low compliance environment of dentinal walls So During acute inflammatory reaction Vasodilatation occurs along with increased capillary permeability Which leads to increase in the pulp interstitial fluid pressure which creates more pressure on blood vessels and this prevents beneficial blood flow which decreases the ability of the pulp to defend itself from bacterial attacks causing tissue necrosis This necrotic tissue is colonized by bacterial tissues
In the literature one of the novel treatment modalities for irrevesible inflammation of the pulp is partial removal of the inflammed pulp tissue according to clinical sign bleeding control The pulp tissue is removed partially until reaching complete coronal pulp removal or complete pulpectomy until hemostasis is obtained after 10 minutes of moist cotton pellet applicationSo The normal pulp is preserved
In 2019 Ricucci et al conducted a systematic review for treatment of deep carious lesions with pulp exposure With treatment modalities ranging from direct pulp capping partial pulpotomy complete pulpotomy and pulpectomy Based only on clinical signs of normal appearance of the pulp tissue under magnification with dental operating microscope and bleeding control within 10 minutes with a moist cotton pellet
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None