Ignite Creation Date:
2024-05-06 @ 5:51 PM
Last Modification Date:
2024-10-26 @ 2:36 PM
Study NCT ID:
NCT05451069
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-10-12
First Post:
2022-06-26
Brief Title:
Neurofilament Light Chain Chitinase-3 Like-1 Proteins and Plasmacytoid Dendritic Cells in Multiple Sclerosis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Combined Neurofilament Light Chain Chitinase-3 Like-1 Protein Levels and Tolerogenic Plasmacytoid Dendritic Cells in Defining Disease Course in Multiple Sclerosis Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Multiple sclerosis MS is an autoimmune neurodegenerative disease characterized by demyelination and neurodegeneration of the central nervous system CNS Current diagnostic criteria and management depend on MRI clinical status and oligoclonal immunoglobulin g bands These markers often fail to predict relapse progression and therapy response There is an increased need to identify biomarkers for clinical endpoints
One of the hallmark features of MS is axonal damage which associated with brain and cervical atrophyNf levels indicate the extent of axonal damage Neurofilaments are composed of four subunits neurofilament light polypeptides NfL is the most abundant and soluble and it is highly sensitive to neurodegenerative processes
Chitinase 3-like 1 CHI3L1 is expressed in astrocytes in the brain tissue of MS patients CHI3L1 plays a role as prognostic biomarker in patients with MS CHI3L1 cerebrospinal fluid levels were associated correlated with disease activity and neurological disability
Dendritic cells DCs are highly specialized antigen-presenting cells with a key role in activating and preventing CNS immune-mediated damage in MS Dendritic cells express Human Leukocyte Antigen-antigen D Related HLA-DR Plasmacytoid dendritic cells characterized by the expression of blood dendritic cells antigen-2 BDCA-2 Plasmacytoid dendritic cells are present in the cerebrospinal fluid CSF leptomeninges and demyelinating lesions of patients with MS Plasmacytoid dendritic cells also exhibit up-regulation of chemokine CCR7C expression It was demonstrated increased amounts of chemokine CCR7 in the CSF from MS patients during relapses CCR7 controls migration and functional activity of regulatory T cells and plays an important role in the establishment of tolerance
Tolerogenic DCs TolDCs present an intermediate phenotype between immature dendritic cells iDCs and mature dendritic cells mDCs regarding costimulatory molecules a pronounced shift toward anti-inflammatory TolDCs exhibit tolerogenic molecules such as HLA-G and CD274 programmed death-ligand 1 PD-L1 either in peripheral blood or in CSF These characteristics lead to T cell clonal anergy and T cell unresponsiveness due to Ag presentation in the presence of low co-stimulation We aim to investigate the role of NfLCHI3L1 and markers of plasmacytoid dendritic cells in MS
One of the hallmark features of MS is axonal damage which associated with brain and cervical atrophyNf levels indicate the extent of axonal damage Neurofilaments are composed of four subunits neurofilament light polypeptides NfL is the most abundant and soluble and it is highly sensitive to neurodegenerative processes
Chitinase 3-like 1 CHI3L1 is expressed in astrocytes in the brain tissue of MS patients CHI3L1 plays a role as prognostic biomarker in patients with MS CHI3L1 cerebrospinal fluid levels were associated correlated with disease activity and neurological disability
Dendritic cells DCs are highly specialized antigen-presenting cells with a key role in activating and preventing CNS immune-mediated damage in MS Dendritic cells express Human Leukocyte Antigen-antigen D Related HLA-DR Plasmacytoid dendritic cells characterized by the expression of blood dendritic cells antigen-2 BDCA-2 Plasmacytoid dendritic cells are present in the cerebrospinal fluid CSF leptomeninges and demyelinating lesions of patients with MS Plasmacytoid dendritic cells also exhibit up-regulation of chemokine CCR7C expression It was demonstrated increased amounts of chemokine CCR7 in the CSF from MS patients during relapses CCR7 controls migration and functional activity of regulatory T cells and plays an important role in the establishment of tolerance
Tolerogenic DCs TolDCs present an intermediate phenotype between immature dendritic cells iDCs and mature dendritic cells mDCs regarding costimulatory molecules a pronounced shift toward anti-inflammatory TolDCs exhibit tolerogenic molecules such as HLA-G and CD274 programmed death-ligand 1 PD-L1 either in peripheral blood or in CSF These characteristics lead to T cell clonal anergy and T cell unresponsiveness due to Ag presentation in the presence of low co-stimulation We aim to investigate the role of NfLCHI3L1 and markers of plasmacytoid dendritic cells in MS
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None