Ignite Creation Date:
2024-05-06 @ 5:51 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05455372
Status:
UNKNOWN
Last Update Posted:
2022-07-13
First Post:
2022-07-08
Brief Title:
Influence of Oral Hp Infection and Oral Related Factors on Gastric Hp Infection and Eradication Therapy
Sponsor:
Second Affiliated Hospital of Xian Jiaotong University
Organization:
Second Affiliated Hospital of Xian Jiaotong University
Study Overview
Official Title:
Analysis of Influencing Factors of Oral Helicobacter Pylori Infection and Oral Related Factors on Gastric Helicobacter Pylori Infection and Eradication Therapy Among the Outpatients of A Tertiary Hospital in Xian
Status:
UNKNOWN
Status Verified Date:
2022-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Hp
Brief Summary:
Helicobacter pylori H pylori is closely related to the occurrence of gastric cancer and other diseases The discovery and eradication of H pylori is of great significance for the prevention and treatment of related diseases Oral H pylori may act as a reservoir to cause H pylori to spread between populations and to cause individual gastric H pylori infection and recurrenceUnderstanding the oral and gastric H pylori infection and influencing factors of the population can provide scientific basis for the formulation of local H pylori infection prevention strategiesAnalyzing the influencing factors of H pylori eradication in the population can improve the local H pylori eradication rate and reduce the recurrence of H pylori infectionTherefore this study intends to analyze the influence of oral H pylori infection and oral related factors on gastric H pylori infection and eradication therapy in outpatients of a tertiary hospital in Xian
Detailed Description:
Taking 300 dyspepsia patients who will undergo C13-urea breath test C13-UBT in the outpatient department of gastroenterology of the Second Affiliated Hospital of Xian Jiaotong University from July 2022 to March 2024 as the research subjects A questionnaire survey on factors related to H pylori infection will be conductedwhich include basic information eating habits living environment and oral care habitsFrom July 2022 to March 2024 Taking 300 patients who will be diagnosed with gastric H pylori infection in the Gastroenterology Department of the Second Affiliated Hospital of Xian Jiaotong University and receive bismuth quadruple H pylori eradication therapy as the research subjectsThe bismuth quadruple regimen is specifically ilaprazole 5mg amoxicillin 1000mg clarithromycin 500mg colloidal bismuth tartrate 220mg bid for 14 daysThe research subjects will be also required to complete a questionnaire survey on factors related to the eradication therapy of gastric H pylorithe contents of the questionnaire include basic information living habits side effects of medication and complianceAll the above populations will be given H pylori Saliva Test Cassette HPS to detect whether H pylori infection in the oral cavity and the oral hygiene score OHI and the permanent tooth decay missing fill index DMF will be also evaluated and recorded4-6 weeks after the end of treatment 13C-UBT will be performed to confirm the results of gastric H pylori eradication and the oral H pylori infection will be re-detected by HPSThe patients with successful eradication therapy of gastric H pylori will be followed up and the recurrence of gastric H pylori will be confirmed by 13C-UBT 1 year later
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None