Ignite Creation Date:
2024-05-05 @ 6:32 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00503087
Status:
UNKNOWN
Last Update Posted:
2007-08-08
First Post:
2007-07-17
Brief Title:
Evaluation of Pain Reduction in the Administration of Saline Injections by the Usage of Pneumatic Skin Flattening
Sponsor:
PalJect Ltd
Organization:
PalJect Ltd
Study Overview
Official Title:
Evaluation of Pain Reduction in the Administration of Saline Injections by the Usage of Pneumatic Skin Flattening PSF
Status:
UNKNOWN
Status Verified Date:
2007-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Each participant will be administered 2 injections of saline - the first in the right gluteal area and the second in the left gluteal area Both injections will be administered intra-muscularly by the same clinician One injection will be given with vacuum Pneumatic Skin Flattening or PSF Machine and the other without vacuum The order of the injections will be randomly assigned Each subject will serve as a control for himself Between injections a 30 min pause will be given to minimize pain sensation bias of the previous injection Immediately after each injection the pain level will be assessed by the VAS scale The researcher assessing the pain will be blinded for the type of injection given The evaluation of the pain reduction will be made by comparison of the pain level with and without the application of the PSF
Hypothesis PSF Technique will reduce the pain associated with saline injections
Hypothesis PSF Technique will reduce the pain associated with saline injections
Detailed Description:
Injections are currently the gold-standard for administrating various medications parenterally The most significant side-effect related to injections is the accompanying pain Injection pain is related to the penetration of the skin by the needle and to the mechanical and chemical effects of the drug during and after its injection This pain remains a major obstacle in medication administration in children as well as in other populations subject to needle-phobia because of the pain experience The associated pain may thus prevent optimized medical care for these patients
Current methods to alleviate immediate pain include the utilization of topical anesthesia whereas some patients do not utilize any form of pain relief and simply endure the pain of the injection Other methods for pain reduction are taking advantage of the applying pressure or vibration to alleviate pain These methods have resulted in a number of pain relieving devices currently on the market Such predicate devices primarily involve vibration devices commonly used to alleviate the injection pain Published data suggests possible use of pressure application mechanism in pain alleviation related to injections
We suggest here for the first time the use of the Pneumatic Skin Flattening PSF technology for alleviation of pain associated with injections The PSF technology is currently used worldwide in the FDA cleared Serenity device Serenity Inolase Ltd for pain reduction in hair removal The device generates contact and compression between a transparent sapphire window and the skin The compression creatures pressure signal which based on the gate theory is though to depress the pain associated with the hair removal treatment We assume the same mechanism would apply for the reduction of pain associated with injections
Comparison Intra-Subject pain level change of injection with PSF and without PSF
Current methods to alleviate immediate pain include the utilization of topical anesthesia whereas some patients do not utilize any form of pain relief and simply endure the pain of the injection Other methods for pain reduction are taking advantage of the applying pressure or vibration to alleviate pain These methods have resulted in a number of pain relieving devices currently on the market Such predicate devices primarily involve vibration devices commonly used to alleviate the injection pain Published data suggests possible use of pressure application mechanism in pain alleviation related to injections
We suggest here for the first time the use of the Pneumatic Skin Flattening PSF technology for alleviation of pain associated with injections The PSF technology is currently used worldwide in the FDA cleared Serenity device Serenity Inolase Ltd for pain reduction in hair removal The device generates contact and compression between a transparent sapphire window and the skin The compression creatures pressure signal which based on the gate theory is though to depress the pain associated with the hair removal treatment We assume the same mechanism would apply for the reduction of pain associated with injections
Comparison Intra-Subject pain level change of injection with PSF and without PSF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None