Ignite Creation Date:
2024-05-06 @ 5:50 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05456022
Status:
UNKNOWN
Last Update Posted:
2022-07-13
First Post:
2022-06-25
Brief Title:
Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line
Status:
UNKNOWN
Status Verified Date:
2022-07
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Squamous cell carcinoma SCC is the most common oral cavity carcinoma Conventional therapeutic modalities for oral malignancy include surgery radiotherapy and chemotherapy alone or in combinationsThe major obstacle of using current anticancer drugs is first the non-specific tissue distribution as these drugs are unable to distinguish between normal and cancer cellsQuercetin is a bioactive flavonoid having strong antioxidant properties Among all the nanomaterials polymeric nanoparticles are of significant interest for drug delivery applications due to many unique features of nanoparticle polymersThis is the first study to investigate the anticancer effects of Quercetin either free or encapsulated by PLGA-PEG NPs in tongue squamous cell carcinoma TSCC cell line
Detailed Description:
Squamous cell carcinoma SCC is the most common oral cavity carcinoma Conventional therapeutic modalities for oral malignancy include surgery radiotherapy and chemotherapy alone or in combinations The major obstacle of using current anticancer drugs is first the non-specific tissue distribution as these drugs are unable to distinguish between normal and cancer cells Quercetin is a bioactive flavonoid having strong antioxidant properties It is naturally present in a wide variety of fruits and vegetables Among all the nanomaterials polymeric nanoparticles are of significant interest for drug delivery applications due to many unique features of nanoparticle polymers Polymeric nanocarriers have been fabricated from natural and synthetic polymers Poly ethylene glycol-poly lactide-co-glycolic acid PEG-PLGA amphiphilic copolymer is an emergent system because it can be easily synthesized and possesses a lot of good qualities Several previous in vitro and in vivo studies have evaluated the cytotoxic effects of quercetin and have revealed that it decreases cell viability and increases cell apoptotic rate in OSCC However the anti-cancer property of quercetin in tongue squamous cell carcinoma TSCC has not been studied yet This is the first study to investigate the anticancer effects of Quercetin either free or encapsulated by PLGA-PEG NPs in tongue squamous cell carcinoma TSCC cell line
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None