Viewing Study NCT05442658



Ignite Creation Date: 2024-05-06 @ 5:49 PM
Last Modification Date: 2024-10-26 @ 2:36 PM
Study NCT ID: NCT05442658
Status: COMPLETED
Last Update Posted: 2022-07-05
First Post: 2022-06-23

Brief Title: Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Sponsor: Chang Gung Memorial Hospital
Organization: Chang Gung Memorial Hospital

Study Overview

Official Title: Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Status: COMPLETED
Status Verified Date: 2022-06
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years particularly in industrialized countries 3-6 of children under 3 years of age and 1-3 of adults Food allergens in children are represented by milk egg wheat soy peanuts tree nuts fish and shellfish The majority of allergic processes that develop during the childhood tend to abate with age whereas those that occur during adulthood tend to persist Hypersensitivity refers to an excessive immunological reaction to food antigens with undesirable consequences

The first aim of our study is to evaluate the role of intestinal microbiota and their relationship with immune tolerance or allergic disorder The second aim of our study is determining the biochemical metabolites on the host human being in allergic disorder and these biochemical metabolites can be measured in fecal or urine samples by metabolomics methods We try to seek to gain an advanced understanding of gut microbiota and biochemical metabolites associated with mucosal immune responses in the host These findings could be useful for developing strategies to modify the gut microbiota or medical applications eg healthy microbe preparations involving beneficial microorganisms to control the development of allergic disorders
Detailed Description: Intestinal microbiota are directly involved in the development of innate and acquired mucosal immune response The gut microbiota also have metabolic synthetic and processing functions in close liaison with the human bodys metabolic processes They are excellent energy anaerobic bioreactors and they can consume store and redistribute the energy produced The gut microbiota also allow us to extract energy from substances not otherwise useful in terms of energy such as indigestible carbohydrates

Intestinal microflora are able to use the substances consumed in the diet bacteria can transform complex polysaccharides and monosaccharides in short-chain fatty acids Short-chain fatty acids are a source of energy for colonocytes and directly affect the storage of lipids and the absorption and metabolism of food creating the so-called second meal effect

Qualitative and quantitative alterations of commensal flora may result in various gastrointestinal and extraintestinal diseases Food hypersensitivity and allergies are an emerging entity in the microbial related diseases universe

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None