Ignite Creation Date:
2024-05-06 @ 5:49 PM
Last Modification Date:
2024-10-26 @ 2:36 PM
Study NCT ID:
NCT05440162
Status:
UNKNOWN
Last Update Posted:
2022-06-30
First Post:
2022-06-27
Brief Title:
Prevelane and Short Term Outcome of Hypernatremic Dehydration in Children With Acute Gastroenteritis in Sohag University Hospital
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Prevelane and Short Term Outcome of Hypernatremic Dehydration in Children With Acute Gastroenteritis in Sohag University Hospital
Status:
UNKNOWN
Status Verified Date:
2022-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hypernatremic dehydration HND is a common and potentially life-threatening condition in children It is defined by a serum level of sodium greater than or equal to 145 mmolL HND is a type of acute dehydration constitutes a medical emergency and requires a rapid diagnosis for adequate and quick management It is characterized by a deficit of total body water TBW relative to total body sodium TBS levels due to either loss of free water or excessive administration of hypertonic sodium solutions It is common in infants Net water loss as seen in diarrhea is the most common cause of hypernatremia Clinical interventions at the hospital settings or accidental sodium loading usually cause hypertonic sodium gain It is common in developing countries where gastroenteritis is a common problem
Most children with hypernatremia are dehydrated and have the typical signs and symptoms as weight loss decreased skin turgor pale skin color and dry mucous membranes Hypernatremia even without dehydration cause central nervous system symptoms according to the degree of sodium elevation and the acuity of the increase Patients are irritable restless weak and lethargic Some infants have a high-pitched cry Alert patients are very thirsty although nausea and fever may be present
HND can lead to neurological impairment due to brain shrinkage which can tear cerebral blood vessels leading to brain hemorrhage Cerebral hemorrhages are the most serious complications of HND that can eventually lead to convulsions and even coma
The first priority in managing a child with HND is to stop the ongoing water loss by treating the underlying cause The next step is to restore the intravascular volume with isotonic fluid Dehydration can be treated with oral nasogastric or intravenous fluids The child is given a fluid bolus usually 20 mLkg of the isotonic solution over about 20 to 30 minutes More severe dehydration needs repeated boluses at a faster rate After the fluid bolus is given the signs of dehydration should be reassessed in order to confirm a complete rehydration Fluid loss should not be corrected rapidly Cerebral edema as well as convulsions is serious risks during rapid rehydration so correction of deficit should be achieved slowly and gradually over 48 hours and should not be decreased to less than 12 mEqL To prevent cerebral edema and convulsion individuals with hypernatremia should be managed in such a way that the reduction rate of serum sodium occurs at approximately 10 to 12 mmolL24 hr
Cerebral edema and seizures can be consequences of rapid correction of serum sodium level in these patients in whom the rate of fluid and sodium administration are inappropriate
Most children with hypernatremia are dehydrated and have the typical signs and symptoms as weight loss decreased skin turgor pale skin color and dry mucous membranes Hypernatremia even without dehydration cause central nervous system symptoms according to the degree of sodium elevation and the acuity of the increase Patients are irritable restless weak and lethargic Some infants have a high-pitched cry Alert patients are very thirsty although nausea and fever may be present
HND can lead to neurological impairment due to brain shrinkage which can tear cerebral blood vessels leading to brain hemorrhage Cerebral hemorrhages are the most serious complications of HND that can eventually lead to convulsions and even coma
The first priority in managing a child with HND is to stop the ongoing water loss by treating the underlying cause The next step is to restore the intravascular volume with isotonic fluid Dehydration can be treated with oral nasogastric or intravenous fluids The child is given a fluid bolus usually 20 mLkg of the isotonic solution over about 20 to 30 minutes More severe dehydration needs repeated boluses at a faster rate After the fluid bolus is given the signs of dehydration should be reassessed in order to confirm a complete rehydration Fluid loss should not be corrected rapidly Cerebral edema as well as convulsions is serious risks during rapid rehydration so correction of deficit should be achieved slowly and gradually over 48 hours and should not be decreased to less than 12 mEqL To prevent cerebral edema and convulsion individuals with hypernatremia should be managed in such a way that the reduction rate of serum sodium occurs at approximately 10 to 12 mmolL24 hr
Cerebral edema and seizures can be consequences of rapid correction of serum sodium level in these patients in whom the rate of fluid and sodium administration are inappropriate
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None