Ignite Creation Date:
2024-05-06 @ 5:48 PM
Last Modification Date:
2024-10-26 @ 2:35 PM
Study NCT ID:
NCT05431023
Status:
UNKNOWN
Last Update Posted:
2022-06-24
First Post:
2022-03-12
Brief Title:
Effect of Lactoferrin in Pneumonia Treatment
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Efficacy of Lactoferrin as Adjunct Therapy for Pneumonia in Children and Adolescents
Status:
UNKNOWN
Status Verified Date:
2022-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pneumonia is defind as the inflammation of lung tissue caused by an infectious agent that results in acute respiratory signs and symptoms Community acquired pneumonia CAP is a major cause of morbidity and increased health care costs In developing nations pneumonia remains a significant cause of mortality in children
Pneumonia occurs in 30 to 45 of every 1000 children under 5 years of age it is less common in 5- to 9-year olds 16 to 221000 and in older children 7 to 161000
Streptococcus pneumoniae is the primary bacterial cause of pneumonia in infants and children Viral etiologies become less prevalent and mycoplasmal and chlamydial infections become more prevalent with increasing age
Pneumonia occurs in 30 to 45 of every 1000 children under 5 years of age it is less common in 5- to 9-year olds 16 to 221000 and in older children 7 to 161000
Streptococcus pneumoniae is the primary bacterial cause of pneumonia in infants and children Viral etiologies become less prevalent and mycoplasmal and chlamydial infections become more prevalent with increasing age
Detailed Description:
Lactoferrin LF is iron-binding glycoprotein of the transferrin family that is expressed and secreted by glandular cells and is found in most body fluids It appears at especially high concentrations in mammalian milk and was first identified in bovine milk and was subsequently isolated from human milk
LFs bacteriostatic function is due to its ability to take up the Fe3 ion limiting use of this nutrient by bacteria at the infection site and inhibiting the growth of these microorganisms as well as the expression of their virulence factors
LFs bacteriostatic function is due to its ability to take up the Fe3 ion limiting use of this nutrient by bacteria at the infection site and inhibiting the growth of these microorganisms as well as the expression of their virulence factors
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None