Ignite Creation Date:
2024-05-05 @ 6:32 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00498849
Status:
UNKNOWN
Last Update Posted:
2007-07-10
First Post:
2007-07-08
Brief Title:
The Changes of Patterns of Microarray in Patients With Obstructive Sleep Apnea
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
The Changes of Patterns of Microarray in Patients With Obstructive Sleep Apnea
Status:
UNKNOWN
Status Verified Date:
2005-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study are 1 To genome-wide profile the gene expression patterns of peripheral blood mononuclear cell PBMC in patients with obstructive sleep apnea OSA 2 To profile the gene expression patterns change before and after treatment with continuous positive airway pressure CPAP 3 To correlate the altered gene expression with the severity of the disease and outcome of OSA patients
Detailed Description:
Obstructive sleep apnea syndrome OSAS is characterized with recurrent collapse of upper airway during sleep and resulted in hypoxia and sleep fragmentation Several systemic and cardiovascular complications have been attributed to OSAS which is caused by hypoxia and bursts of sympathetic activity Increase of inflammatory mediators which included C-reactive protein oxidative stress adhesion molecules vascular endothelial growth factor and proinflammatory cytokines were thought to involve in the developments of cardiovascular diseases in patients with OSAS In our preliminary study both serum levels of IL-6 and CRP were higher in patients with OSAS than control subjects and the levels were inversely correlated with the lowest pulse oxygen saturation Factors triggering inflammatory cascades in OSAS included hypoxia and sympathetic hyperactivity
Hypoxia was thought to be the trigger factor for the elevated production of inflammatory mediators Through the induction of transcriptional factors and critical signaling pathways hypoxia induces several physiologic responses like increased anaerobic metabolism angiogenesis vasodilation erythropoiesis and increased breathing
Microarray is the more mature gene analysis techniques so far which can allow high throughput analysis of the function of many genes Microarray can be used to understand the disease mechanisms and is also very useful to improve disease diagnosis disease classification prognosis evaluation and to improve treatment outcome In this project we use oligo microarray to genome-wide profile the altered gene expressions in peripheral blood mononuclear cells of OSAS patients and to correlate the dysregulations of gene expression with the clinical outcome We will also examine the gene expression patterns change before and after treatment with CPAP The information obtained by this approach will be very useful to understand the pathogenic mechanism of OSAS that leads to the systemic and cardiovascular complications Further therapeutic intervention may therefore be possible
Hypoxia was thought to be the trigger factor for the elevated production of inflammatory mediators Through the induction of transcriptional factors and critical signaling pathways hypoxia induces several physiologic responses like increased anaerobic metabolism angiogenesis vasodilation erythropoiesis and increased breathing
Microarray is the more mature gene analysis techniques so far which can allow high throughput analysis of the function of many genes Microarray can be used to understand the disease mechanisms and is also very useful to improve disease diagnosis disease classification prognosis evaluation and to improve treatment outcome In this project we use oligo microarray to genome-wide profile the altered gene expressions in peripheral blood mononuclear cells of OSAS patients and to correlate the dysregulations of gene expression with the clinical outcome We will also examine the gene expression patterns change before and after treatment with CPAP The information obtained by this approach will be very useful to understand the pathogenic mechanism of OSAS that leads to the systemic and cardiovascular complications Further therapeutic intervention may therefore be possible
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC 94-2314-B-002-218- | None | None | None |