Ignite Creation Date:
2024-05-06 @ 5:46 PM
Last Modification Date:
2024-10-26 @ 2:35 PM
Study NCT ID:
NCT05422313
Status:
UNKNOWN
Last Update Posted:
2022-06-22
First Post:
2022-06-14
Brief Title:
Assessment of Galectin-9 in Rheumatoid Arthritis and Its Correlation With Disease Activity
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Assessment of Galectin-9 in Rheumatoid Arthritis and Its Correlation With Disease Activity
Status:
UNKNOWN
Status Verified Date:
2022-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Rheumatoid arthritis RA is an autoimmune disease in which a symmetrical Synovial inflammation bone destruction occur in both small and big Joints If left untreated this illness does not generally cause death but it does drastically affect the quality of life and life expectancy of patients Although there is no cure for RA patients are generally on long-term long-acting disease-modifying anti-rheumatic medications DMARDs to control joint inflammation reduce joint damage maintain joint function and keep the illness in remission
RA disease activity could be detected be DAS28 score The DAS28 is a four-item scale that gives an absolute number reflecting disease activity It includes the number of swollen and tender joints SJC TJC the visual analogue scale of patients assessment of their general health VAS-GH and the erythrocyte sedimentation rate ESR in the first hour
In the pathophysiology of RA cytokine networks play a crucial role Rheumatoid inflammation has been linked to the generation of proinflammatory cytokines throughout time Increased cytokine levels such as tumour necrosis factor TNF and interleukin-6 IL-6 represent rheumatoid synovial inflammation and have been linked to RA disease activity and anti-cytokine therapeutic response The relationship between circulating cytokine levels and the phenotype of RA illness is however poorly understood
Anti-citrullinated peptide antibodies ACPA are effective in the diagnosis of RA and have been linked to joint destruction progression and therapy response in RA patients However the relationship between ACPA status and proinflammatory cytokines during the course of RA illness is yet unknown
Galectins are lectins with carbohydrate recognition domains CRDs that are extremely similar in sequence and exclusively bind to β--galactoside carbs There are at least 15 galectins found in mammals each having one or two CRDs comprising roughly 130 amino acids Galectins have a wide range of activities due to their ubiquitous distribution including mRNA splicing programmed cell death cell cycle control activation adhesion migration and cell differentiation
Galectin-9 Gal-9 is abundantly present in lymph nodes bone marrow liver thymus and spleen It is expressed by immune cells endothelial cells and fibroblasts and plays an important role in regulating inflammation and immune reactions Gal-9 is a ligand for T cell immunoglobulin and mucin-containing-moleculte-3 Tim-3 that is expressed on CD4 T helper Th 1 and Th17 and sends inhibitory signals to Tim-3 As a result of its interaction with Tim-3 Gal-9 suppresses pro-inflammatory T cell responses and the Gal-9Tim-3 pathway causes apoptosis of CD4 Th1 or Th17 cells
Considering that RA is a Th1-polarized autoimmune illness dysregulated Gal-9 levels may induce an innateadaptive immunity imbalance resulting in pathological rheumatoid inflammation Gal-9 has been demonstrated to mediate angiogenesis and inflammatory cell infiltration in inflammatory arthritis
These findings show that Gal-9 may have a role in the inflammatory processes of rheumatoid arthritis As a result we concentrated on Gal-9 and postulated that it could be involved in the pathogenesis of RA The levels of serum Gal-9 in individuals with RA were studied in this study and the results were compared to clinical indicators
RA disease activity could be detected be DAS28 score The DAS28 is a four-item scale that gives an absolute number reflecting disease activity It includes the number of swollen and tender joints SJC TJC the visual analogue scale of patients assessment of their general health VAS-GH and the erythrocyte sedimentation rate ESR in the first hour
In the pathophysiology of RA cytokine networks play a crucial role Rheumatoid inflammation has been linked to the generation of proinflammatory cytokines throughout time Increased cytokine levels such as tumour necrosis factor TNF and interleukin-6 IL-6 represent rheumatoid synovial inflammation and have been linked to RA disease activity and anti-cytokine therapeutic response The relationship between circulating cytokine levels and the phenotype of RA illness is however poorly understood
Anti-citrullinated peptide antibodies ACPA are effective in the diagnosis of RA and have been linked to joint destruction progression and therapy response in RA patients However the relationship between ACPA status and proinflammatory cytokines during the course of RA illness is yet unknown
Galectins are lectins with carbohydrate recognition domains CRDs that are extremely similar in sequence and exclusively bind to β--galactoside carbs There are at least 15 galectins found in mammals each having one or two CRDs comprising roughly 130 amino acids Galectins have a wide range of activities due to their ubiquitous distribution including mRNA splicing programmed cell death cell cycle control activation adhesion migration and cell differentiation
Galectin-9 Gal-9 is abundantly present in lymph nodes bone marrow liver thymus and spleen It is expressed by immune cells endothelial cells and fibroblasts and plays an important role in regulating inflammation and immune reactions Gal-9 is a ligand for T cell immunoglobulin and mucin-containing-moleculte-3 Tim-3 that is expressed on CD4 T helper Th 1 and Th17 and sends inhibitory signals to Tim-3 As a result of its interaction with Tim-3 Gal-9 suppresses pro-inflammatory T cell responses and the Gal-9Tim-3 pathway causes apoptosis of CD4 Th1 or Th17 cells
Considering that RA is a Th1-polarized autoimmune illness dysregulated Gal-9 levels may induce an innateadaptive immunity imbalance resulting in pathological rheumatoid inflammation Gal-9 has been demonstrated to mediate angiogenesis and inflammatory cell infiltration in inflammatory arthritis
These findings show that Gal-9 may have a role in the inflammatory processes of rheumatoid arthritis As a result we concentrated on Gal-9 and postulated that it could be involved in the pathogenesis of RA The levels of serum Gal-9 in individuals with RA were studied in this study and the results were compared to clinical indicators
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None