Ignite Creation Date:
2024-05-06 @ 5:45 PM
Last Modification Date:
2024-10-26 @ 2:35 PM
Study NCT ID:
NCT05418894
Status:
RECRUITING
Last Update Posted:
2023-07-12
First Post:
2022-06-06
Brief Title:
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Sponsor:
Baylor College of Medicine
Organization:
Baylor College of Medicine
Study Overview
Official Title:
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression Pursuing this signal from a novel platform with invasive intracranial recording electrodes provides much-needed spatial and temporal resolution to characterize the neural dynamics of socio-affective processing The investigators will leverage first-in-human intracranial neural recording opportunities created by a novel therapeutic platform termed stereotactic electroencephalography-informed deep brain stimulation stereo-EEG-informed DBS as well as the powerful platform of intracranial stereotactic recording and stimulation in patients undergoing epilepsy surgical evaluation at Baylor College of Medicine The sEEG-informed DBS trial provides unique opportunities for intracranial recording of affect-relevant network regions in patients with treatment-resistant depression TRD Recordings in identical regions in epilepsy patients who themselves often demonstrate mild-moderate depressive symptoms will provide a wide dynamic range across the symptom spectrum To provide critical data on the spatiotemporal dynamics of socio-affective processing the investigators will leverage these two human intracranial recording and stimulation cohorts to study the precise structural functional and causal properties of the affective salience network Greater understanding of the social processing circuitry mediated by the affective salience network may be used to drive therapeutic innovation pioneering a new paradigm that improves socio-emotional function across a wide variety of neuropsychiatric conditions The results from this proposal have the potential to improve the lives of patients with dysfunction in social affective processing with implications for a wide range of neuropsychiatric diseases
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None