Ignite Creation Date:
2024-05-06 @ 5:45 PM
Last Modification Date:
2024-10-26 @ 2:34 PM
Study NCT ID:
NCT05413109
Status:
RECRUITING
Last Update Posted:
2024-05-10
First Post:
2022-06-07
Brief Title:
COMPression of Left Main coRonary artEry in patientS With Pulmonary Arterial Hypertension aSymptomatIc fOr aNgina
Sponsor:
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Organization:
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study Overview
Official Title:
COMPression of Left Main coRonary artEry in patientS With Pulmonary Arterial Hypertension aSymptomatIc fOr aNgina
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COMPRESSION
Brief Summary:
The prevalence of critical ab extrinsic compression of left main coronary artery LMCA is very high in patients with pulmonary arterial hypertension PAH symptomatic for angina up to 40 according to a recent study of 121 patients with PAH The element that most of all correlates with the degree of coronary stenosis is the diameter of the pulmonary artery PA In particular a diameter 40 mm has a sensitivity of 83 and a specificity of 70 in patients with angina Critical stenosis of LMCA is a risk factor for sudden death and in these condition percutaneous coronary angioplasty with stent implantation has proven to be a safe and effective long-term procedure Preliminary data from a retrospective analysis of the registry of patients with PAH in Bologna ARCA registry 1092016UOss highlights that even in PAH patients asymptomatic for angina compression of LMCA can occur in up to 13 of patients and the main predictive parameter of compression was found to be a diameter 42 mm with a sensitivity of 87 and a specificity of 77 Performing a screening test by coronary-CT scan in all subjects suffering of PAH with a PA diameter 40 mm even if asymptomatic for angina could therefore help to identify patients with PAH at increased risk for sudden death at an early stage
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None