Viewing Study NCT05419596



Ignite Creation Date: 2024-05-06 @ 5:44 PM
Last Modification Date: 2024-10-26 @ 2:35 PM
Study NCT ID: NCT05419596
Status: UNKNOWN
Last Update Posted: 2022-06-15
First Post: 2022-06-10

Brief Title: The Analysis of Gene Variants Related to POCD in Elderly Patients
Sponsor: Istanbul University
Organization: Istanbul University

Study Overview

Official Title: The Analysis of Gene Variants Related to POCD in Elderly Patients a Prospective Observational Study
Status: UNKNOWN
Status Verified Date: 2022-06
Last Known Status: NOT_YET_RECRUITING
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: The pathophysiology of postoperative cognitive dysfunction POCD following surgery may be related to Alzheimers disease Different studies show that low levels of glial cell line-derived growth factor are found in both POCD and Alzheimer and brain cholinergic markers like Choline acetyl transferase activity High affinity choline uptake activity and Acetil Choline Ach activity are decreased in Alzheimer diseaseWe know cholinergic inputs in the basal forebrain have a critical role in many other functions including memory attention arousal and sensory processing

Cholinergic neuron located basal section of forebrain degenerate extensively in Alzheimer disease which shares similarities with postoperative delirium and POCD Ach binds to two well-known receptors in brain that are Nicotinic receptors which implicate several important functions such as memory learning arousal and reward and Muscarinic receptors which are widely distributed in forebrain and play an important role of development delirium and POCD Dysfunction of cholinergic system may be one key aspect of postoperative DELIRIUM POCD and ALZHEIMER disease

In this investigation we would like to evaluate the relationship between genes encoding inflammation-related mediators detected in postoperative cognitive dysfunction and gene variants in Alzheimers disease in a larger panel for elder patients undergoing major urologic surgery Therefore our study will focus on demographic information of the patients age gender comorbidity neurocognitive tests 1 week before the surgery postoperative 1st week and postoperative 3rd month intraoperative data mean arterial pressure heart rate need for inotrope duration of mechanical ventilation need for transfusion and biochemical tests Preoperative and postoperative blood samples for each patient which are APOE phosphatidylinositol-binding clathrin assembly protein CR1 - complement receptor 1 ATP-binding cassette transporter IL6 TREM
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None