Ignite Creation Date:
2024-05-06 @ 5:44 PM
Last Modification Date:
2024-10-26 @ 2:34 PM
Study NCT ID:
NCT05413434
Status:
COMPLETED
Last Update Posted:
2023-08-15
First Post:
2022-03-06
Brief Title:
Exercise Training and Respiratory Muscle Training in Individuals With Metabolic SyndromeMETS
Sponsor:
Hacettepe University
Organization:
Hacettepe University
Study Overview
Official Title:
The Effects of Exercise Training and Respiratory Muscle Training on Physical Fitness Pulmonary Functions and METS Parameters in Individuals With METS
Status:
COMPLETED
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
METS
Brief Summary:
The study will be conducted on individuals with Metabolic Syndrome There are many studies showing that aerobic exercise provides significant improvements in waist circumference fasting glucose high-density lipoprotein cholesterol HDL-C Triglyceride TG systolic and diastolic blood pressure SBP-DBP and cardiorespiratory fitness on METS parameters However although the beneficial effects of physical activity are known only half of the population adheres to the 150 minutes of moderate-intensity physical activity per week recommendation High-intensity interval training HIIT is a type of training that uses near-maximal intensities in short-term sessions HIIT has been used to improve compliance because it requires less time to treat patients with cardiometabolic disease Compared to continuous aerobic exercise this type of training has been shown to be an effective alternative for improving maximum oxygen consumption VO2 max blood pressure heart function glucose and lipid metabolism and markers of oxidative stress and inflammation In the literature HIIT has been studied in patients with METS and has been shown to be effective In addition a study showed that seven-day respiratory muscle training was also effective on METS parameters but there is no study showing the long-term effects of respiratory muscle training in this patient group Therefore in our study researchers aimed to show the effects of respiratory muscle training given with HIIT on METS parameters
Detailed Description:
Metabolic syndrome METS is a systemic endocrinopathy characterized by the presence of risk factors such as abdominal obesity glucose intolerance or diabetes mellitus atherogenic dyslipidemia hypertension and a persistent proinflammatory profile According to the International Diabetes Federation IDF definition of METS almost 20-25 of the adult world population has METS and people with METS are at risk of heart attack stroke type 2 diabetes T2D all-cause and cardiovascular death approximately three times higher In addition modifiable risk factors such as physical inactivity diet and sedentary behavior have all been associated with increased prevalence of METS Increasing incidence of METS increase in morbidity and mortality necessitated the implementation of preventive strategies and the implementation of pharmacological and non-pharmacological treatments
Studies in the literature have shown that vagal tone decreases and sympathetic tone increases in patients with METS At the same time impaired baroreflex sensitivity and decreased heart rate variability are observed in these patients Changes in autonomic modulation cause the release of some bioactive molecules by affecting the endocrine and immune systems In this case increased sympathetic autonomic tone creates a cardiometabolic risk In adults with METS autonomic dysfunction appears to be more prominent in women than in men Autonomic functions are impaired due to changes such as loss of lean body mass increase in fat mass increase in body mass redistribution of fat from the periphery to the middle parts of the body especially in postmenopausal women As a result increased blood pressure impaired endothelial function decreased glucose tolerance and atherogenic changes in lipid and coagulation profiles can be observed This increases the incidence of METS in postmenopausal women Therefore strategies to reduce the risk of metabolic syndrome have often been studied on women in the literature and there is a need for studies involving men and new strategies
Physical activity and exercise training are recommended as key prescriptions for the prevention and treatment of METS and low-grade chronic inflammation Increase in physical exercise has been recommended for the prevention and primary treatment of cardiovascular disease CVD and METS because of the cardioprotective benefits associated with improved cardiorespiratory fitness CRF There are many studies showing that aerobic exercise provides significant improvements in waist circumference fasting glucose high-density lipoprotein cholesterol HDL-C TG systolic and diastolic blood pressure SBP-DBP and cardiorespiratory fitness on METS parameters However although the beneficial effects of physical activity are known only half of the population adheres to the 150 minutes of moderate-intensity physical activity per week recommendation It has been shown that one of the main barriers to reaping health benefits and being more active is lack of time High-intensity interval training HIIT is a type of training that uses near-maximal intensities in short-term sessions HIIT has been used to improve compliance because it requires less time to treat patients with cardiometabolic disease Compared to continuous aerobic exercise this type of training is an effective alternative to improve maximum oxygen consumption VO2max blood pressure heart function glucose and lipid metabolism and markers of oxidative stress and inflammation However it has been seen that there are not enough studies on HIIT effectiveness on METS parameters in the literature Therefore researchers aimed to show the effects of HIIT training applied together with respiratory muscle training on METS parameters in patients with METS
It has shown the beneficial effects of exercise training as well as inspiratory muscle training IME on autonomic function in patients with hypertension and heart disease In a study it was shown that 7-day inspiratory muscle training improved respiratory muscle functions and cardiac autonomic functions in postmenopausal women As a result of this study inspiratory muscle training has been proposed as a nonpharmacological strategy to improve autonomic modulation and reduce risk factors in individuals with METS but further studies are required to confirm the long-term effects or effects of inspiratory muscle training in addition to classical exercise training protocols such as aerobic resistance or combined training are needed
In a study conducted in healthy and middle-aged men and postmenopausal women in 2021 it was proven that high resistance inspiratory muscle strength training can improve blood pressure control and vascular endothelial function and reduce the risk of cardiovascular disease and other clinical disorders In this study researchers presented the first evidence that inspiratory muscle strength training increases NO bioavailability decreases systemic inflammation and causes potentially beneficial changes in the plasma metabolome by increasing endothelial NO synthase activation and decreasing oxidative stress In conclusion it has been shown that inspiratory muscle strength training can be used as a promising lifestyle intervention to improve cardiovascular function and reduce the risk of other clinical disorders
Since the long-term effects of respiratory muscle training in individuals with METS have not been examined in the literature researchers planned this study to examine the effects of inspiratory muscle strength training added to aerobic exercise training HIIT on physical fitness respiratory functions and METS parameters in individuals with METS
Studies in the literature have shown that vagal tone decreases and sympathetic tone increases in patients with METS At the same time impaired baroreflex sensitivity and decreased heart rate variability are observed in these patients Changes in autonomic modulation cause the release of some bioactive molecules by affecting the endocrine and immune systems In this case increased sympathetic autonomic tone creates a cardiometabolic risk In adults with METS autonomic dysfunction appears to be more prominent in women than in men Autonomic functions are impaired due to changes such as loss of lean body mass increase in fat mass increase in body mass redistribution of fat from the periphery to the middle parts of the body especially in postmenopausal women As a result increased blood pressure impaired endothelial function decreased glucose tolerance and atherogenic changes in lipid and coagulation profiles can be observed This increases the incidence of METS in postmenopausal women Therefore strategies to reduce the risk of metabolic syndrome have often been studied on women in the literature and there is a need for studies involving men and new strategies
Physical activity and exercise training are recommended as key prescriptions for the prevention and treatment of METS and low-grade chronic inflammation Increase in physical exercise has been recommended for the prevention and primary treatment of cardiovascular disease CVD and METS because of the cardioprotective benefits associated with improved cardiorespiratory fitness CRF There are many studies showing that aerobic exercise provides significant improvements in waist circumference fasting glucose high-density lipoprotein cholesterol HDL-C TG systolic and diastolic blood pressure SBP-DBP and cardiorespiratory fitness on METS parameters However although the beneficial effects of physical activity are known only half of the population adheres to the 150 minutes of moderate-intensity physical activity per week recommendation It has been shown that one of the main barriers to reaping health benefits and being more active is lack of time High-intensity interval training HIIT is a type of training that uses near-maximal intensities in short-term sessions HIIT has been used to improve compliance because it requires less time to treat patients with cardiometabolic disease Compared to continuous aerobic exercise this type of training is an effective alternative to improve maximum oxygen consumption VO2max blood pressure heart function glucose and lipid metabolism and markers of oxidative stress and inflammation However it has been seen that there are not enough studies on HIIT effectiveness on METS parameters in the literature Therefore researchers aimed to show the effects of HIIT training applied together with respiratory muscle training on METS parameters in patients with METS
It has shown the beneficial effects of exercise training as well as inspiratory muscle training IME on autonomic function in patients with hypertension and heart disease In a study it was shown that 7-day inspiratory muscle training improved respiratory muscle functions and cardiac autonomic functions in postmenopausal women As a result of this study inspiratory muscle training has been proposed as a nonpharmacological strategy to improve autonomic modulation and reduce risk factors in individuals with METS but further studies are required to confirm the long-term effects or effects of inspiratory muscle training in addition to classical exercise training protocols such as aerobic resistance or combined training are needed
In a study conducted in healthy and middle-aged men and postmenopausal women in 2021 it was proven that high resistance inspiratory muscle strength training can improve blood pressure control and vascular endothelial function and reduce the risk of cardiovascular disease and other clinical disorders In this study researchers presented the first evidence that inspiratory muscle strength training increases NO bioavailability decreases systemic inflammation and causes potentially beneficial changes in the plasma metabolome by increasing endothelial NO synthase activation and decreasing oxidative stress In conclusion it has been shown that inspiratory muscle strength training can be used as a promising lifestyle intervention to improve cardiovascular function and reduce the risk of other clinical disorders
Since the long-term effects of respiratory muscle training in individuals with METS have not been examined in the literature researchers planned this study to examine the effects of inspiratory muscle strength training added to aerobic exercise training HIIT on physical fitness respiratory functions and METS parameters in individuals with METS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None