Ignite Creation Date:
2024-05-06 @ 5:43 PM
Last Modification Date:
2024-10-26 @ 2:34 PM
Study NCT ID:
NCT05409651
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-05-06
First Post:
2022-05-16
Brief Title:
Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention
Sponsor:
University of California San Diego
Organization:
University of California San Diego
Study Overview
Official Title:
Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The mechanisms underlying POTS are not well understood Though heterogeneous in nature patients often present with symptoms that include fatigue orthostatic lightheadedness and tachycardia brain fog shortness of breath and sleep disruption The central mediator that links observations in disease entities similar to POTS is energy use and balance driven by mitochondrial health Mitochondrial dysfunction ie respiration defects reactive oxygen species ROS generation and structural abnormalities are hallmarks of currently defined syndromes that resemble POTS symptomatology Many patients with POTS have underlying immune system dysfunction which when treated may improve the patients overall health Though autoimmunity has been demonstrated in POTS overall immune dysregulation may be broader and include immune cell exhaustion and persistent inflammatory cytokine responses Immune dysfunction including cellular exhaustion and persistent inflammation has been linked to mitochondrial function Therefore we hypothesize that a unifying feature of POTS results from latent or continued mitochondrialimmune dysfunction which then impacts multi-organ energy imbalance and immune homeostasis Understanding and targeting mitochondria utilizing established novel and directed approaches including time-restricted eating TRE will help to unravel common etiologies and help us to better diagnose manage and treat POTS
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None