Ignite Creation Date:
2024-05-05 @ 6:31 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00493701
Status:
COMPLETED
Last Update Posted:
2022-09-15
First Post:
2007-06-26
Brief Title:
ADAPT The Adaptation to High Fat Diets Extention
Sponsor:
Pennington Biomedical Research Center
Organization:
Pennington Biomedical Research Center
Study Overview
Official Title:
ADAPT-The Adaptation to High Fat Diets
Status:
COMPLETED
Status Verified Date:
2022-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to predict weight gain overtime after a high fat diet
Detailed Description:
In the past 3 years we have identified a thrifty-phenotype characterized in lean men by an inability to adapt rapidly to a high fat diet and associated with a low maximal VO2 and high fasting insulin We hypothesize that the individuals with the thrifty phenotype are at higher risk for becoming obese and that exercise may be effective in overcoming this problem
Several questions remain to be answered regarding the thrifty phenotype First given the large interindividual differences how can we identify those at the highest risk What are the distinguishing biochemical endocrine and environmental characteristics of individuals that store fat when exposed to high fat diets This is important because if these individuals can be easily identified then dietary interventions can be targeted to this at-risk population
Second what is different about the individual with the thrifty phenotype Are there cellular pathways that are dysregulated in the skeletal muscle of these individuals when compared to controls Is the defect intrinsic ie a diminished ability to conserve glucose and oxidize fat in skeletal muscle or alternately is the phenotype due to environmental and dietary factors such as inactivity and energy excess
To answer these questions we have planned a three-year project that aims to
Characterize the biochemical endocrine anthropometric and environmental characteristics of individuals with the thrifty phenotype
Identify the signaling pathways in skeletal muscle that are dysregulated in individuals with the thrifty phenotype through mRNA expression profiling in skeletal tissue
Determine the role of environmental factors such as inactivity and caloric intake vs intrinsic genetic factors in the thrifty phenotype
Several questions remain to be answered regarding the thrifty phenotype First given the large interindividual differences how can we identify those at the highest risk What are the distinguishing biochemical endocrine and environmental characteristics of individuals that store fat when exposed to high fat diets This is important because if these individuals can be easily identified then dietary interventions can be targeted to this at-risk population
Second what is different about the individual with the thrifty phenotype Are there cellular pathways that are dysregulated in the skeletal muscle of these individuals when compared to controls Is the defect intrinsic ie a diminished ability to conserve glucose and oxidize fat in skeletal muscle or alternately is the phenotype due to environmental and dietary factors such as inactivity and energy excess
To answer these questions we have planned a three-year project that aims to
Characterize the biochemical endocrine anthropometric and environmental characteristics of individuals with the thrifty phenotype
Identify the signaling pathways in skeletal muscle that are dysregulated in individuals with the thrifty phenotype through mRNA expression profiling in skeletal tissue
Determine the role of environmental factors such as inactivity and caloric intake vs intrinsic genetic factors in the thrifty phenotype
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None