Ignite Creation Date:
2024-05-05 @ 6:30 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00496613
Status:
COMPLETED
Last Update Posted:
2022-04-21
First Post:
2007-07-03
Brief Title:
Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors
Sponsor:
Memorial Sloan Kettering Cancer Center
Organization:
Memorial Sloan Kettering Cancer Center
Study Overview
Official Title:
Chemotherapy-Induced Cognitive Change and DNA Damage in Breast Cancer Survivors
Status:
COMPLETED
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to learn more about how chemotherapy affects an individuals thinking abilities cognition Some research has shown that chemotherapy can cause changes in cognition in breast cancer survivors However it is not clear why this change occurs In this study the investigators will look to see if damage to DNA is related to these changes in cognition Specifically the investigators want to see 1 if women who have been treated with chemotherapy have more DNA damage than healthy women and 2 if DNA damage is related to cognitive problems in breast cancer survivors and healthy women
Detailed Description:
The primary objective of this proposal is to obtain preliminary data regarding the association between DNA damage and cognitive functioning in breast cancer survivors Specifically we predict that
1 Breast cancer survivors treated with chemotherapy and hormonal therapy will have higher levels of DNA damage as measured by the Comet assay as compared to age and education matched survivors treated with hormonal therapy only and healthy controls
2 Survivors who meet criteria for cognitive impairment will have higher levels of DNA damage as compared to cancer survivors who do not meet criteria for cognitive impairment and healthy controls
1 Breast cancer survivors treated with chemotherapy and hormonal therapy will have higher levels of DNA damage as measured by the Comet assay as compared to age and education matched survivors treated with hormonal therapy only and healthy controls
2 Survivors who meet criteria for cognitive impairment will have higher levels of DNA damage as compared to cancer survivors who do not meet criteria for cognitive impairment and healthy controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None