Ignite Creation Date:
2024-05-06 @ 5:39 PM
Last Modification Date:
2024-10-26 @ 2:33 PM
Study NCT ID:
NCT05384340
Status:
RECRUITING
Last Update Posted:
2023-01-12
First Post:
2022-04-17
Brief Title:
NO3-rich Beet Juice and Exercise on Postmenopausal Women Cardiovascular Health
Sponsor:
University of Sao Paulo
Organization:
University of Sao Paulo
Study Overview
Official Title:
Nitrate-rich Beet Juice Intake and Aerobic Exercise on Cardiovascular Health of Postmenopausal Women With Arterial Hypertension
Status:
RECRUITING
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the context of physical exercise there is no evidence of the acute and continued use of beetroot juice with a previously recommended dose of nitrate NO3 300mg on the cardiovascular performance of hypertensive and postmenopausal women We will investigate the effects of beetroot juice rich in NO3 acutely first day 140mL800mg and during a week with daily doses second to the seventh day 70mL400mg on blood pressure heart rate HR cardiac autonomic control EF inflammatory hormonal and stress biomarkers oxidative stress and enzymes involved in nitric oxide synthesis and mitochondrial regulation under resting conditions as well as mediated by submaximal aerobic exercise sessions Through a randomized crossover triple-blind placebo-controlled clinical trial 20 physically inactive hypertensive women will undergo an acute and 7-day trial each with two intervention protocols 1 placebo and 2 beetroot in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval On collection days exercise will be performed on a treadmill for 40 minutes at a speed corresponding to 65-70 of VO2peak The collection of variables cardiovascular autonomic and blood samples for molecular analyses of the study will take place at rest 120 minutes after ingestion of the intervention during exercise 40 minutes and in the effort recovery stage during 65 minutes based on previously validated protocols The collections were arranged so that the measurement of one variable does not interfere with the other and that they have adequate intervals between them
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None