Ignite Creation Date:
2024-05-06 @ 5:39 PM
Last Modification Date:
2024-10-26 @ 2:33 PM
Study NCT ID:
NCT05382611
Status:
COMPLETED
Last Update Posted:
2022-05-19
First Post:
2022-05-16
Brief Title:
miRNA in Patients With Thoracic Abdominal and Intracranial Aneurysms
Sponsor:
Na Homolce Hospital
Organization:
Na Homolce Hospital
Study Overview
Official Title:
miRNA in Patients With Thoracic Abdominal and Intracranial Aneurysms
Status:
COMPLETED
Status Verified Date:
2022-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
miRNA
Brief Summary:
To assess the expression of miRNA in patients with TAA AAA in aneurysmatic tissue and to compare this expression with the healthy tissue in the same patient
In the same cohort to asses the presence of miRNA in plasma and to compare with the control group
Over the period of three yearsto follow subjects in order to assess if the presence of certain miRNAs speeds up or slows down the progression of disease
In patients with intracranial aneurysms to detect miRNA in plasma especially in patients with familial occurrence
In the same cohort to asses the presence of miRNA in plasma and to compare with the control group
Over the period of three yearsto follow subjects in order to assess if the presence of certain miRNAs speeds up or slows down the progression of disease
In patients with intracranial aneurysms to detect miRNA in plasma especially in patients with familial occurrence
Detailed Description:
MicroRNAs constitute a recently discovered class of non-coding RNAs that play key roles in the regulation of gene expression Acting at the post-transcriptional level MicroRNAs have been shown to be involved in a wide range of biological processes such as cell cycle control apoptosis and several developmental and physiological processes including stem cell differentiation hematopoiesis hypoxia cardiac and skeletal muscle development In addition to their important roles in healthy individuals microRNAs have also been implicated in a number of diseases including a broad range of cancers cardiovascular and heart disease Their different expression in aortic tissue in patients with aortic abdominal aneurysm and their association with the progression of the disease were confirmed They represent the potential target for the treatment of the disease MiRNA act as biomarkers showing the potential risk of the presence of TAA AAA and intracranial aneurysm for the prediction of TAA and AAA progression and for the discovery of new treatment possibilities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None