Ignite Creation Date:
2024-05-05 @ 6:30 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00497757
Status:
COMPLETED
Last Update Posted:
2020-08-31
First Post:
2007-07-06
Brief Title:
Induction of Donor Specific Tolerance in Recipients of Cardiac Allografts by Donor Stem Cell Infusion
Sponsor:
Suzanne T Ildstad
Organization:
University of Louisville
Study Overview
Official Title:
1 Induction of Donor-Specific Tolerance in Recipients of Cardiac Allografts by Donor Stem Cell Infusion 2 Induction of Donor-Specific Tolerance by Donor Facilitating Cell FC Stem Cell Infusion in Recipients of Hepatic Allografts
Status:
COMPLETED
Status Verified Date:
2020-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this research study is to establish chimerism and avoid graft-versus-host disease in patients who need a heart transplant
Detailed Description:
At the present time heart transplant recipients must take anti-rejection medication to prevent rejection of the donated heart Even with this medication chronic rejection is the most common cause of late graft loss The anti-rejection agents themselves are significantly toxic with side effects including kidney damage infection and an increased incidence of cancer The goal of this study is to allow the patient to develop tolerance to the transplanted heart while maintaining a competent immune system Tolerance enables the transplant recipients body to recognize the transplanted organ as self rather than foreign tissue The recipient will not try to reject the donor heart and the need for anti-rejection medication could be dramatically decreased or eliminated entirely To accomplish this patients in this study will receive specially treated bone marrow taken from their heart donor Bone marrow transplant has been shown in animal studies and in humans to induce tolerance following organ transplant
Two factors limit the application of donor marrow transplant to induce tolerance 1 preparing the patient for transplant conditioning and 2 graft-versus-host disease GVHD Traditional conditioning destroys the recipients immune system and requires that the marrow transplant be successful because the patient is unable to fight off infection if the donor cells do not survive GVHD occurs when donor immune cells recognize the recipients cells as foreign tissue and attack them Severe GVHD can result in death This study utilizes a new approach to conditioning which leaves the patients immune system intact The transplant product is depleted of GVHD-producing cells but retains tolerance-promoting facilitating cells which are intended to ensure the donor and recipient cells coexists peacefully a state called mixed chimerism The toxicity of conditioning and transplantation is significantly reduced
In this study we will determine the appropriate cell dose to safely establish mixed chimerism following partial conditioning in heart transplant recipients The study takes a gradual approach to increasing the cell dose to achieve mixed chimerism We believe this study will provide a breakthrough in the approach to heart transplantation Our goal is to evaluate the potential of safely establishing mixed chimerism to induce tolerance following heart transplant and reduce or eliminate the need for anti-rejection therapy
Two factors limit the application of donor marrow transplant to induce tolerance 1 preparing the patient for transplant conditioning and 2 graft-versus-host disease GVHD Traditional conditioning destroys the recipients immune system and requires that the marrow transplant be successful because the patient is unable to fight off infection if the donor cells do not survive GVHD occurs when donor immune cells recognize the recipients cells as foreign tissue and attack them Severe GVHD can result in death This study utilizes a new approach to conditioning which leaves the patients immune system intact The transplant product is depleted of GVHD-producing cells but retains tolerance-promoting facilitating cells which are intended to ensure the donor and recipient cells coexists peacefully a state called mixed chimerism The toxicity of conditioning and transplantation is significantly reduced
In this study we will determine the appropriate cell dose to safely establish mixed chimerism following partial conditioning in heart transplant recipients The study takes a gradual approach to increasing the cell dose to achieve mixed chimerism We believe this study will provide a breakthrough in the approach to heart transplantation Our goal is to evaluate the potential of safely establishing mixed chimerism to induce tolerance following heart transplant and reduce or eliminate the need for anti-rejection therapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None