Ignite Creation Date:
2024-05-06 @ 5:38 PM
Last Modification Date:
2024-10-26 @ 2:33 PM
Study NCT ID:
NCT05386940
Status:
COMPLETED
Last Update Posted:
2022-05-23
First Post:
2022-05-15
Brief Title:
Protein Kinase N1 Level in Patients Undergoing Cardiac Surgery
Sponsor:
Zhongnan Hospital
Organization:
Zhongnan Hospital
Study Overview
Official Title:
Protein Kinase N1 Level Predicts Acute Kidney Injury in Patients Undergoing Cardiac Surgery
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute kidney injury AKI is one of the most frequent major complications in patients undergoing cardiac surgery CSA-AKI is independently related to increased perioperative mortality increased hospital and ICU length of stay as well as heath care expenditure Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors Recently it has been shown that Protein kinase N1 PKN1 is associated with ischemia-reperfusion injury In this study relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated
Detailed Description:
Acute kidney injury AKI is one of the most frequent major complications in patients undergoing cardiac surgery The incidence of cardiac surgery-associated AKI CSA-AKI varies from 5 to 42 and is the second leading cause of AKI after sepsis in the intensive care unit ICU CSA-AKI is independently related to increased perioperative mortality increased hospital and ICU length of stay as well as heath care expenditure Early detection of CSA-AKI could improve patient outcomes and health care costs through targeted interventions Thus identification of relevant biomarkers may lead to early diagnosis The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors Recently it has been shown that Protein kinase N1 PKN1 is associated with ischemia-reperfusion injury Nowadays little is known about relationship between PKN1 and CSA-AKI In this study relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None