Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005524
Status:
COMPLETED
Last Update Posted:
2016-01-12
First Post:
2000-05-25
Brief Title:
Mental Stress Autonomic Function and Heart Disease
Sponsor:
Hebrew SeniorLife
Organization:
Hebrew SeniorLife
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the vagal vascular sympathetic and mechno-structural components of baroreflex regulation in coronary artery disease CAD patients and healthy age-matched controls during rest and acute laboratory stress
Detailed Description:
BACKGROUND
The strong association between mental stress and morbid cardiovascular events in coronary artery disease CAD patients may derive from stress-induced cardiac ischemia due to exaggerated increases in vascular resistance and arterial pressure In fact this may explain part of the prognostic relationship of baroreflex cardiac vagal control to cardiovascular outcome among CAD patients The hemodynamic responses to psychological stress are buffered by the arterial baroreflex thus exaggerated pressor responses to mental stress may result from impaired baroreflex regulation in CAD patients
DESIGN NARRATIVE
The study has three components The first component characterizes the relationships between vascular stiffness and baroreflex regulation among CAD patients also contrasting healthy control subjects with CAD patients The second component examines in relation to individual differences in pharmacologically derived estimates of baroreflex function changes in autonomic and baroreflex control during laboratory psychological stress among CAD patients and among healthy control subjects The third component tests the hypothesis that impaired baroreflex regulation in CAD patients due to increased vascular stiffness andor attenuated autonomic control is associated with exacerbated hemodynamic reactions to psychological stress Bolus vasoactive drug infusions in combination with Finapres beat-by-beat arterial pressures and carotid B-mode ultrasonography are used to evaluate baroreflex sensitivity and arterial stiffness Baroreflex adjustments to psychological stress are assessed by power spectral-derived relations between arterial pressure and cardiac chronotropy during a mental arithmetic task and a speech task The degree to which indices of baroreflex function are associated with hemodynamic responses to psychological stress among CAD patients is assessed
The strong association between mental stress and morbid cardiovascular events in coronary artery disease CAD patients may derive from stress-induced cardiac ischemia due to exaggerated increases in vascular resistance and arterial pressure In fact this may explain part of the prognostic relationship of baroreflex cardiac vagal control to cardiovascular outcome among CAD patients The hemodynamic responses to psychological stress are buffered by the arterial baroreflex thus exaggerated pressor responses to mental stress may result from impaired baroreflex regulation in CAD patients
DESIGN NARRATIVE
The study has three components The first component characterizes the relationships between vascular stiffness and baroreflex regulation among CAD patients also contrasting healthy control subjects with CAD patients The second component examines in relation to individual differences in pharmacologically derived estimates of baroreflex function changes in autonomic and baroreflex control during laboratory psychological stress among CAD patients and among healthy control subjects The third component tests the hypothesis that impaired baroreflex regulation in CAD patients due to increased vascular stiffness andor attenuated autonomic control is associated with exacerbated hemodynamic reactions to psychological stress Bolus vasoactive drug infusions in combination with Finapres beat-by-beat arterial pressures and carotid B-mode ultrasonography are used to evaluate baroreflex sensitivity and arterial stiffness Baroreflex adjustments to psychological stress are assessed by power spectral-derived relations between arterial pressure and cardiac chronotropy during a mental arithmetic task and a speech task The degree to which indices of baroreflex function are associated with hemodynamic responses to psychological stress among CAD patients is assessed
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL059332 | NIH | None | httpsreporternihgovquickSearchR01HL059332 |