Ignite Creation Date:
2024-05-06 @ 5:36 PM
Last Modification Date:
2024-10-26 @ 2:32 PM
Study NCT ID:
NCT05368597
Status:
COMPLETED
Last Update Posted:
2022-05-16
First Post:
2022-05-06
Brief Title:
CompArison of PCI in NaTive Arteries Versus ByPAss Grafts In PatieNts With Prior CABG CAPTAIN
Sponsor:
Beijing Anzhen Hospital
Organization:
Beijing Anzhen Hospital
Study Overview
Official Title:
Comparison of Percutaneous Coronary Intervention in Native Arteries Versus Bypass Grafts in Patients With Prior Coronary Artery Bypass Grafting
Status:
COMPLETED
Status Verified Date:
2022-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary atherosclerotic heart disease CAD has been considered the leading cause of death in both developed and developing countries Coronary artery bypass grafting CABG is a major therapy of CAD in the world mainly used for patients with left main disease multi-vessel complex disease stent implantation failure heart failure and diabetes
Studies have demonstrated that significant angiographic defects up to 12 of grafts which was observed by immediate coronary angiography after CABG Despite secondary prevention were performed in patients after CABG the early failure rate at 1 year is higher up to 15-20 the 10-year patency rate of internal mammary artery graft is 85 and the 10-year patency rate of saphenous vein graft is only 61 and 10-20 of patients require revascularization within 10 years after CABG
Patients with failed grafts usually have a higher surgical risk and the morality of repeat CABG is 2-4 times higher than primary surgery Because of the poor clinical prognosis of patients undergoing repeat CABG PCI is the preferred treatment strategy for revascularization in patients with previous CABG In patients with previous CABG approximately 75 of PCI target vessels are native vessels
Compared with native vessel PCI bypass graft PCI has a higher rate of short- and long-term major adverse events including more than double the in-hospital mortality rate Some studies support the above viewbut others denied Therefore the primary study mainly to explore the effect of native vessel PCI or graft PCI on the prognosis of patients with previous CABG
Studies have demonstrated that significant angiographic defects up to 12 of grafts which was observed by immediate coronary angiography after CABG Despite secondary prevention were performed in patients after CABG the early failure rate at 1 year is higher up to 15-20 the 10-year patency rate of internal mammary artery graft is 85 and the 10-year patency rate of saphenous vein graft is only 61 and 10-20 of patients require revascularization within 10 years after CABG
Patients with failed grafts usually have a higher surgical risk and the morality of repeat CABG is 2-4 times higher than primary surgery Because of the poor clinical prognosis of patients undergoing repeat CABG PCI is the preferred treatment strategy for revascularization in patients with previous CABG In patients with previous CABG approximately 75 of PCI target vessels are native vessels
Compared with native vessel PCI bypass graft PCI has a higher rate of short- and long-term major adverse events including more than double the in-hospital mortality rate Some studies support the above viewbut others denied Therefore the primary study mainly to explore the effect of native vessel PCI or graft PCI on the prognosis of patients with previous CABG
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None