Ignite Creation Date:
2024-05-06 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 2:31 PM
Study NCT ID:
NCT05358093
Status:
UNKNOWN
Last Update Posted:
2022-05-03
First Post:
2022-03-30
Brief Title:
Cardiac Toxicity of Hypo Fractionated Radiotherapy in Left Breast Cancer
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Retrospective Study of Cardiac Toxicity of Hypo Fractionated Radiotherapy in Left Breast Cancer
Status:
UNKNOWN
Status Verified Date:
2022-04
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Worldwide Breast cancer is the most common cancer in womenwhere 17 million new cases diagnosed in 2012 In 2020 number doubled as 23 million women diagnosed with breast cancer According to ACS 1 in 8 women in United states will develop breast cancer in her life
Similarly again In Egypt breast cancer is the most common malignancy in women about 22700 new cases recorded in 2020 Accounting for 388 of cancers in this population and forecasted to be approximately 46000 in 2050
Post-operative radiotherapy is fundamental part of treatment after either conservative surgery or mastectomy Conventionally fractionated radiation therapy CFRT Delivering 45-50 GY in 18-2 GY daily fractions for 5 days per week over 5-7 weeks was the standard schedule to eradicate sub clinical disease sparing normal tissues After the publication of long term results of randomized controlled trials RCTs comparing safety and effectiveness of hypo fractionated RT HFRTdelivered in3 weeks vs CFRT in node negative BC has been implemented in 2008 numerous international guidelines recommended HFRT as the new standard being Cost effectiveness limited resources excessively long RT waiting lists Another important argument for HFRT utilization even assuming alphabeta of 15GY is biologically milder or isoeffective for healthy tissues compered to CFRT
Cardiac toxicity is potentially long or short term complication of various anticancer therapies systemic therapy as anthracyclines or biological agent implicated in causing irreversible cardiac dysfunction
Radiotherapy also have cardio toxic effect through different mechanisms
Similarly again In Egypt breast cancer is the most common malignancy in women about 22700 new cases recorded in 2020 Accounting for 388 of cancers in this population and forecasted to be approximately 46000 in 2050
Post-operative radiotherapy is fundamental part of treatment after either conservative surgery or mastectomy Conventionally fractionated radiation therapy CFRT Delivering 45-50 GY in 18-2 GY daily fractions for 5 days per week over 5-7 weeks was the standard schedule to eradicate sub clinical disease sparing normal tissues After the publication of long term results of randomized controlled trials RCTs comparing safety and effectiveness of hypo fractionated RT HFRTdelivered in3 weeks vs CFRT in node negative BC has been implemented in 2008 numerous international guidelines recommended HFRT as the new standard being Cost effectiveness limited resources excessively long RT waiting lists Another important argument for HFRT utilization even assuming alphabeta of 15GY is biologically milder or isoeffective for healthy tissues compered to CFRT
Cardiac toxicity is potentially long or short term complication of various anticancer therapies systemic therapy as anthracyclines or biological agent implicated in causing irreversible cardiac dysfunction
Radiotherapy also have cardio toxic effect through different mechanisms
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None