Ignite Creation Date:
2024-05-05 @ 5:36 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00498329
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2007-07-07
Brief Title:
Brain Function in Performance of Motor Tasks
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Brain Connectivity and Sensorimotor Integration During DualSingle Motor Tasks
Status:
COMPLETED
Status Verified Date:
2011-11-18
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the areas in the brain are connected when they are controlling two finger movements at the same time It will look at how people use what they see to help guide two different movements This ability which is important in everyday life can be a problem for patients with neurological problems
Healthy right-handed volunteers 18 years of age and older may be eligible for this study Candidates are screened with a medical history physical examination and magnetic resonance imaging MRI of the brain MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues The MRI scanner is a metal cylinder surrounded by a strong magnetic field The subject lies on a table that can slide in and out of the scanner wearing earplugs to muffle loud noises that occur during the scanning
Participants undergo functional MRI fMRI This is a standard MRI that is done while the subject performs skilled finger tasks in response to instructions they see on a screen Researchers localize brain areas which show activity changes while the tasks are performed Before the test session begins subjects complete a questionnaire and have an opportunity to practice the task
Subjects control the position of one or two cursors on a screen using one or two fingers They perform tracking or pointing tasks according to what they see on the screen During the single-task experiment only one task is presented on the screen During the dual-task experiment two tasks are presented on the screen Subjects perform either the single-task or dual-task experiment but not both The fMRI lasts about 90 minutes with subjects asked to lie still during the scan for up to 9 minutes at a time
After completing the fMRI subjects are scheduled for a research electroencephalogram EEG and magnetoencephalogram MEG The test is done while the subject performs tasks so that researchers can learn about the timing of changes in activity in certain brain regions during performance of the same tasks done for the fMRI
Healthy right-handed volunteers 18 years of age and older may be eligible for this study Candidates are screened with a medical history physical examination and magnetic resonance imaging MRI of the brain MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues The MRI scanner is a metal cylinder surrounded by a strong magnetic field The subject lies on a table that can slide in and out of the scanner wearing earplugs to muffle loud noises that occur during the scanning
Participants undergo functional MRI fMRI This is a standard MRI that is done while the subject performs skilled finger tasks in response to instructions they see on a screen Researchers localize brain areas which show activity changes while the tasks are performed Before the test session begins subjects complete a questionnaire and have an opportunity to practice the task
Subjects control the position of one or two cursors on a screen using one or two fingers They perform tracking or pointing tasks according to what they see on the screen During the single-task experiment only one task is presented on the screen During the dual-task experiment two tasks are presented on the screen Subjects perform either the single-task or dual-task experiment but not both The fMRI lasts about 90 minutes with subjects asked to lie still during the scan for up to 9 minutes at a time
After completing the fMRI subjects are scheduled for a research electroencephalogram EEG and magnetoencephalogram MEG The test is done while the subject performs tasks so that researchers can learn about the timing of changes in activity in certain brain regions during performance of the same tasks done for the fMRI
Detailed Description:
Objective
Using a block design BOLD-fMRI we want to investigate the connectivity in brain regions when two motor responses are performed in the same time The designs will be replicated using EEG and MEG to understand the time course of the activated brain network better It will allow us to map the brain processes involved in sensorimotor integration and attentional sharing
Study Population
160 individuals subdivided in
110 adult healthy volunteers
25 patients with Parkinson Disease
25 patients with Focal Hand Dystonia
Design
Two experiments will be performed using MEG EEG and fMRI techniques Both experiments will use visuo-motor control tasks Two motor responses given by two fingers of the dominant hand will be simultaneously performed Experiment 1 will use single motor tasks Experiment 2 will use dual motor tasks In both experiments the attention demands will vary with the execution mode of the motor outputs competitive or cooperative In competitive tasks the visual stimuli will be used to perform two independent motor outputs In cooperative tasks the visual stimuli will be used to perform two coupled motor outputs The effect of the execution mode on brain connectivity will be isolated comparing competitive and cooperative tasks The sensory information must be associated to the motor command to perform a given motor task this process is called sensorimotor integration With both experiments we will be able to dissociate the network connectivity linked to
sensorimotor integration demands for focused attention in a single task
sensorimotor integration demands for divided attention in a dual motor task
After subjects have been properly trained to perform the tasks they will undergo fMRI scanning MEG and EEG recording Subjects will perform the tasks presented pseudo-randomly during six sets of 5-minute sessions We will record their muscular activity via EMG surface electrodes
Outcome Measures
The primary outcomes are the task-dependent functional connectivity for fMRI between areas and coherence for MEG and EEG of cerebral sources relative to performance of the tasks The force control of two fingers in the same time would elicit blood oxygen level dependent BOLD signal and electrical brain activity variations in the network involved in manual dexterity We are interested in studying the connectivity between the homologous motor areas of the two hemispheres and between prefrontal cortex and parietal cortex to understand sensorimotor integration processes during competitive and cooperative dual tasks As a second measure we are interested in analyzing coherence between MEG-EMG and EEG-EMG signals
Using a block design BOLD-fMRI we want to investigate the connectivity in brain regions when two motor responses are performed in the same time The designs will be replicated using EEG and MEG to understand the time course of the activated brain network better It will allow us to map the brain processes involved in sensorimotor integration and attentional sharing
Study Population
160 individuals subdivided in
110 adult healthy volunteers
25 patients with Parkinson Disease
25 patients with Focal Hand Dystonia
Design
Two experiments will be performed using MEG EEG and fMRI techniques Both experiments will use visuo-motor control tasks Two motor responses given by two fingers of the dominant hand will be simultaneously performed Experiment 1 will use single motor tasks Experiment 2 will use dual motor tasks In both experiments the attention demands will vary with the execution mode of the motor outputs competitive or cooperative In competitive tasks the visual stimuli will be used to perform two independent motor outputs In cooperative tasks the visual stimuli will be used to perform two coupled motor outputs The effect of the execution mode on brain connectivity will be isolated comparing competitive and cooperative tasks The sensory information must be associated to the motor command to perform a given motor task this process is called sensorimotor integration With both experiments we will be able to dissociate the network connectivity linked to
sensorimotor integration demands for focused attention in a single task
sensorimotor integration demands for divided attention in a dual motor task
After subjects have been properly trained to perform the tasks they will undergo fMRI scanning MEG and EEG recording Subjects will perform the tasks presented pseudo-randomly during six sets of 5-minute sessions We will record their muscular activity via EMG surface electrodes
Outcome Measures
The primary outcomes are the task-dependent functional connectivity for fMRI between areas and coherence for MEG and EEG of cerebral sources relative to performance of the tasks The force control of two fingers in the same time would elicit blood oxygen level dependent BOLD signal and electrical brain activity variations in the network involved in manual dexterity We are interested in studying the connectivity between the homologous motor areas of the two hemispheres and between prefrontal cortex and parietal cortex to understand sensorimotor integration processes during competitive and cooperative dual tasks As a second measure we are interested in analyzing coherence between MEG-EMG and EEG-EMG signals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 07-N-0187 | None | None | None |