Ignite Creation Date:
2024-05-06 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 2:31 PM
Study NCT ID:
NCT05345366
Status:
COMPLETED
Last Update Posted:
2024-06-06
First Post:
2022-04-19
Brief Title:
The Correlation Between CITED2 and Collateral Circulation in Acute Ischemic Stroke
Sponsor:
Zhujiang Hospital
Organization:
Zhujiang Hospital
Study Overview
Official Title:
The Impact of CITED2 on Collateral Circulation and Early Neurological Functional Outcome for Ischemic Stroke by Critically Regulating HIF-1α-VEGF Pathway
Status:
COMPLETED
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Evaluating the collateral circulation of acute ischemic stroke AIS mainly depends on the imaging examination At present there is no effective and sensitive biomarker for collateral circulation Thus the research objective was to evaluate the predicting role of the CBPP300-interacting transactivator with GluAsp-rich C-terminal domain 2 Ratio CITED2 from peripheral blood mononuclear cells in the collateral circulation of AIS We classified the AIS patients into two groups the good collateral group and the poor collateral group by DWI-ASPECTS score The western blot was applied to test the protein expression of vascular endothelial growth factor VEGF and CITED2 Then we collected other clinical data Binary logistic regression analysis between collateral circulation and clinical data was performed Finally Receiver operating characteristic ROC curve analysis was used to explore the predictive value of the CITED2
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None