Ignite Creation Date:
2024-05-06 @ 5:31 PM
Last Modification Date:
2024-10-26 @ 2:30 PM
Study NCT ID:
NCT05335668
Status:
RECRUITING
Last Update Posted:
2023-09-13
First Post:
2022-04-12
Brief Title:
Brain Circuitry Changes in Central Poststroke Pain a Clinical and Neuroimaging Study
Sponsor:
Insel Gruppe AG University Hospital Bern
Organization:
Insel Gruppe AG University Hospital Bern
Study Overview
Official Title:
Brain Circuitry Changes in Central Poststroke Pain a Clinical and Neuroimaging Study
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Central poststroke pain CPP is estimated to affect up to 10 of stroke patients and is one of the most difficult-to-treat conditions with a detrimental effect on patients quality of life So far no drug has proven efficient to alleviate CPP and neuromodulation approaches including Deep Brain Stimulation DBS and motor-cortex stimulation have yielded mixed results with only a few patients experiencing long-term pain relief To date little is known about the pathophysiology of CPP There is at present little evidence for a clear association between the specific location of lesions clinical manifestation and phenomenology of pain as well as treatment response of CPP patients Furthermore the time delay between stroke occurrence and CPP occurrence is highly variable and the fact that it is not immediate in the great majority of patients suggests that other factors contribute to the development of CPP These factors have not been identified yet
Detailed Description:
Central poststroke pain CPP is estimated to affect up to 10 of stroke patients and is one of the most difficult-to-treat conditions with a detrimental effect on patients quality of life So far no drug has proven efficient to alleviate CPP and neuromodulation approaches including DBS and motor-cortex stimulation have yielded mixed results with only a few patients experiencing long-term pain relief To date little is known about the pathophysiology of CPP There is at present little evidence for a clear association between the specific location of lesions clinical manifestation and phenomenology of pain as well as treatment response of CPP patients Furthermore the time delay between stroke occurrence and CPP occurrence is highly variable and the fact that it is not immediate in the great majority of patients suggests that other factors contribute to the development of CPP These factors have not been identified yet
The objective of this research project is to correlate clinical aspects of CPP pain phenomenology with magnetic resonance image MRI-based findings especially metabolic changes and functional reorganization processes captured by functional MRI and MR spectroscopy A better understanding of the underlying pathophysiological mechanism of CPP and its involved neuronal networks are mandatory for any future therapeutic approach to treat this difficult condition The discovery of a potential image-based biomarker could serve to help identify patients early who are at risk of developing CPP Furthermore the findings may help identify prognosticators of different forms of CPP treatments eg biofeed-back neuromodulation approaches medication in the future
The objective of this research project is to correlate clinical aspects of CPP pain phenomenology with magnetic resonance image MRI-based findings especially metabolic changes and functional reorganization processes captured by functional MRI and MR spectroscopy A better understanding of the underlying pathophysiological mechanism of CPP and its involved neuronal networks are mandatory for any future therapeutic approach to treat this difficult condition The discovery of a potential image-based biomarker could serve to help identify patients early who are at risk of developing CPP Furthermore the findings may help identify prognosticators of different forms of CPP treatments eg biofeed-back neuromodulation approaches medication in the future
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None