Ignite Creation Date:
2024-05-06 @ 5:30 PM
Last Modification Date:
2024-10-26 @ 2:30 PM
Study NCT ID:
NCT05335824
Status:
COMPLETED
Last Update Posted:
2022-04-19
First Post:
2022-04-08
Brief Title:
The Effect of Autologous Platelet Concentrations on Orthodontic Treatment Time
Sponsor:
Damascus University
Organization:
Damascus University
Study Overview
Official Title:
Comparison Between The Effect of Platelet Rich Plasma PRP and Injectable Platelet Rich Fibrin I-PRF on Orthodontic Tooth Movement
Status:
COMPLETED
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
60 patients needed therapeutic extraction of the maxillary first premolars with subsequent retraction of the maxillary canines were divided to randomly three groups
1 PRP group Received PRP injections 2 I-PRF group Received I-PRF injections 3 Control group conventional treatment with no injections TPAs were used as an anchor unit Coil springs were used to distalize the upper canines on 0019 x 0025-inch stainless archwires Alginate impressions and dental casts of the maxillary arch were done at five-time points over a 4-month follow-up period The amount of canine movement canine rotation and anchorage loss were measured on three-dimensional digital models superimposed on the rugae area
1 PRP group Received PRP injections 2 I-PRF group Received I-PRF injections 3 Control group conventional treatment with no injections TPAs were used as an anchor unit Coil springs were used to distalize the upper canines on 0019 x 0025-inch stainless archwires Alginate impressions and dental casts of the maxillary arch were done at five-time points over a 4-month follow-up period The amount of canine movement canine rotation and anchorage loss were measured on three-dimensional digital models superimposed on the rugae area
Detailed Description:
One of the most important goals of orthodontic treatment is to decrease the treatment time via achieving faster tooth movement chiefly in adults Adults have more bone density and less bone turnover than adolescence which may be linked to potential root resorption periodontal problems and white spot lesions
Approaches to reduce orthodontic treatment time included surgical and non-surgical techniques Non-surgical approaches such as systemic and local administration of chemical substances low-level laser therapy vibrations and pulsed electrical stimulation therapy still need more studies to determine their safety and effectiveness
Surgical procedures such as corticotomy corticision and micro-osteoperforations have
in general high success rates but they rely on incurring an injury to bone tissues The latter has been linked to the regional acceleratory phenomenon RAP But the invasive nature of these procedures associated risks of loss of alveolar bone and gingival recession and the help needed from another specialist limit its routine application Recently the possibility of using platelet-based preparations from the patients blood to accelerate orthodontic tooth movement like platelet-rich plasma PRP and platelet-rich fibrin PRF has grown PRF represents the second generation of biological materials derived from blood It is obtained through a centrifuge of the patients blood without adding any additives to the tube The variety of growth factors in PRP and PRF may have the ability to stimulate the activation of osteoblasts and osteoclasts together which supports the idea that PRP could affect orthodontic tooth movement The study sample consisted of 60 patients and was calculated using G-power sample size calculator depending on the rate of canine retraction with a study power of 90
After ensuring the patients compliance with the terms and conditions of this study the purpose and methods of the study were explained to the patients using Information Sheet In case of approval to participate the patients were asked to sign the informed consent Extra Intra-oral photographs impressions and clinical examinations were made
Canine retraction was initiated after completion of the leveling and alignment phase via closed nickel-titanium coil springs applying 150 g of force per side at the same time
Approaches to reduce orthodontic treatment time included surgical and non-surgical techniques Non-surgical approaches such as systemic and local administration of chemical substances low-level laser therapy vibrations and pulsed electrical stimulation therapy still need more studies to determine their safety and effectiveness
Surgical procedures such as corticotomy corticision and micro-osteoperforations have
in general high success rates but they rely on incurring an injury to bone tissues The latter has been linked to the regional acceleratory phenomenon RAP But the invasive nature of these procedures associated risks of loss of alveolar bone and gingival recession and the help needed from another specialist limit its routine application Recently the possibility of using platelet-based preparations from the patients blood to accelerate orthodontic tooth movement like platelet-rich plasma PRP and platelet-rich fibrin PRF has grown PRF represents the second generation of biological materials derived from blood It is obtained through a centrifuge of the patients blood without adding any additives to the tube The variety of growth factors in PRP and PRF may have the ability to stimulate the activation of osteoblasts and osteoclasts together which supports the idea that PRP could affect orthodontic tooth movement The study sample consisted of 60 patients and was calculated using G-power sample size calculator depending on the rate of canine retraction with a study power of 90
After ensuring the patients compliance with the terms and conditions of this study the purpose and methods of the study were explained to the patients using Information Sheet In case of approval to participate the patients were asked to sign the informed consent Extra Intra-oral photographs impressions and clinical examinations were made
Canine retraction was initiated after completion of the leveling and alignment phase via closed nickel-titanium coil springs applying 150 g of force per side at the same time
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None