Ignite Creation Date:
2024-05-06 @ 5:29 PM
Last Modification Date:
2024-10-26 @ 2:30 PM
Study NCT ID:
NCT05326724
Status:
RECRUITING
Last Update Posted:
2022-04-13
First Post:
2022-03-28
Brief Title:
The Role of Acupuncture-induced Exosome in Treating Post-stroke Dementia
Sponsor:
China Medical University Hospital
Organization:
China Medical University Hospital
Study Overview
Official Title:
The Role of Acupuncture-induced Exosome in Treating Post-stroke Dementia
Status:
RECRUITING
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Stroke is the main cause of disability and the second main cause of dementia Approximately 215 of patients develop dementia within 4 years after stroke The main clinical manifestation of dementia is memory and cognitive impairment At present acetylcholinesterase inhibitors and NMDA glutamate receptor antagonists were used for dementia treatment but those drugs have limited efficacy Exosome is an extracellular vesicle from the endosomal size range from 40 to 160 nm average 100 nm It contains many cells including DNA RNA fat and metabolites as well as cytoplasm and cell surface proteins that play a role in regulating intercellular communication Some studies believe that exosomes in the circulation are an ideal marker to reflect the pathological progress and recovery of stroke and play a key role in the reorganization of tissues and the progress of neurodegeneration after stroke Our previous studies have known that acupuncture can increase the long-term potentiation of hippocampal CA1 in rats with ischemic stroke and improve learning-memory and neurological function Therefore the purpose of this study is to explore the role of acupuncture-induced exosome in the treatment of post-stroke dementia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None