Ignite Creation Date:
2024-05-05 @ 5:35 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00485186
Status:
WITHDRAWN
Last Update Posted:
2013-09-05
First Post:
2007-06-08
Brief Title:
Gene Polymorphisms Influencing Steroid Synthesis and Action
Sponsor:
University Hospital Schleswig-Holstein
Organization:
University Hospital Schleswig-Holstein
Study Overview
Official Title:
Investigation of Gene Polymorphisms Influencing Steroid Synthesis and Action in Patients With Deficient Steroid Biosynthesis and Disorders of Sex Development
Status:
WITHDRAWN
Status Verified Date:
2013-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The extend of steroid biosynthesis and action is mainly dependent on underlying genetic polymorphisms and gene mutations These sequence variations in multiple genes involved in steroid biosynthesis and action cause different diseases for example congenital adrenal hyperplasia or disorders of sex development In addition sequence variations in several other genes may influence the severity of a genetically caused disease of steroid biosynthesis or action By this the differences in an observed phenotype may be explained Within the study all genes necessary for adrenal and gonadal steroid biosynthesis and several genes which are known to influence the action of steroid hormones will be analysed in patients with congenital disorders of adrenal and gonadal steroid biosynthesis disorders of steroid action and disorders of sex development The primary aim is to set up a correlation of the disease phenotype with the different genotypes detected
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None